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Gene Review

Rasa1  -  RAS p21 protein activator (GTPase...

Rattus norvegicus

Synonyms: GAP, GAPX, GTPase-activating protein, Ras GTPase-activating protein 1, Ras p21 protein activator, ...
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Disease relevance of Rasa1


High impact information on Rasa1


Biological context of Rasa1


Anatomical context of Rasa1


Associations of Rasa1 with chemical compounds


Enzymatic interactions of Rasa1


Regulatory relationships of Rasa1


Other interactions of Rasa1


Analytical, diagnostic and therapeutic context of Rasa1


  1. Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells. Hers, I., Wherlock, M., Homma, Y., Yagisawa, H., Tavaré, J.M. J. Biol. Chem. (2006) [Pubmed]
  2. Reconstitution of alpha2D-adrenergic receptor coupling to phospholipase D in a PC12 cell lysate. Jinsi-Parimoo, A., Deth, R.C. J. Biol. Chem. (1997) [Pubmed]
  3. Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP. Pei, L., Teves, R.L., Wallace, M.C., Gurd, J.W. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  4. Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons. Iida, N., Namikawa, K., Kiyama, H., Ueno, H., Nakamura, S., Hattori, S. J. Neurosci. (2001) [Pubmed]
  5. RGS8 accelerates G-protein-mediated modulation of K+ currents. Saitoh, O., Kubo, Y., Miyatani, Y., Asano, T., Nakata, H. Nature (1997) [Pubmed]
  6. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Mohammadi, M., Dionne, C.A., Li, W., Li, N., Spivak, T., Honegger, A.M., Jaye, M., Schlessinger, J. Nature (1992) [Pubmed]
  7. Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Margolis, B., Hu, P., Katzav, S., Li, W., Oliver, J.M., Ullrich, A., Weiss, A., Schlessinger, J. Nature (1992) [Pubmed]
  8. Association between GTPase activators for Rho and Ras families. Settleman, J., Albright, C.F., Foster, L.C., Weinberg, R.A. Nature (1992) [Pubmed]
  9. The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization. Cukierman, E., Huber, I., Rotman, M., Cassel, D. Science (1995) [Pubmed]
  10. Ras GTPase-activating protein binds to Akt and is required for its activation. Yue, Y., Lypowy, J., Hedhli, N., Abdellatif, M. J. Biol. Chem. (2004) [Pubmed]
  11. A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. Homma, Y., Emori, Y. EMBO J. (1995) [Pubmed]
  12. Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity. Oinuma, I., Katoh, H., Negishi, M. J. Cell Biol. (2006) [Pubmed]
  13. Beta PDGF receptor mutants defective for mitogenesis promote neurite outgrowth in PC12 cells. Vetter, M.L., Bishop, J.M. Curr. Biol. (1995) [Pubmed]
  14. Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion. Yang, J.Y., Walicki, J., Abderrahmani, A., Cornu, M., Waeber, G., Thorens, B., Widmann, C. J. Biol. Chem. (2005) [Pubmed]
  15. Interactions of p62(dok) with p210(bcr-abl) and Bcr-Abl-associated proteins. Bhat, A., Johnson, K.J., Oda, T., Corbin, A.S., Druker, B.J. J. Biol. Chem. (1998) [Pubmed]
  16. An effector-like function of Ras GTPase-activating protein predominates in cardiac muscle cells. Abdellatif, M., Schneider, M.D. J. Biol. Chem. (1997) [Pubmed]
  17. Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. Oh, J.S., Manzerra, P., Kennedy, M.B. J. Biol. Chem. (2004) [Pubmed]
  18. The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. Sadoshima, J., Izumo, S. EMBO J. (1996) [Pubmed]
  19. Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes. DePaolo, D., Reusch, J.E., Carel, K., Bhuripanyo, P., Leitner, J.W., Draznin, B. Mol. Cell. Biol. (1996) [Pubmed]
  20. Identification of the ras GTPase-activating protein GAP1(m) as a phosphatidylinositol-3,4,5-trisphosphate-binding protein in vivo. Lockyer, P.J., Wennström, S., Kupzig, S., Venkateswarlu, K., Downward, J., Cullen, P.J. Curr. Biol. (1999) [Pubmed]
  21. Role of tyrosine kinase and phosphotyrosine phosphatase in growth of the intestinal crypt cell (IEC-6) line. Raid, A., Oliver, B., Abdelrahman, A., Sha'afi, R.I., Hajjar, J.J. Proc. Soc. Exp. Biol. Med. (1993) [Pubmed]
  22. Germ-line mutational analysis of the TSC2 gene in 90 tuberous-sclerosis patients. Au, K.S., Rodriguez, J.A., Finch, J.L., Volcik, K.A., Roach, E.S., Delgado, M.R., Rodriguez, E., Northrup, H. Am. J. Hum. Genet. (1998) [Pubmed]
  23. Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein. Bouton, A.H., Kanner, S.B., Vines, R.R., Wang, H.C., Gibbs, J.B., Parsons, J.T. Mol. Cell. Biol. (1991) [Pubmed]
  24. Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Cantor, S.B., Urano, T., Feig, L.A. Mol. Cell. Biol. (1995) [Pubmed]
  25. ARFGAP1 promotes the formation of COPI vesicles, suggesting function as a component of the coat. Yang, J.S., Lee, S.Y., Gao, M., Bourgoin, S., Randazzo, P.A., Premont, R.T., Hsu, V.W. J. Cell Biol. (2002) [Pubmed]
  26. Rab3A GTPase-activating protein-inhibiting activity of Rabphilin-3A, a putative Rab3A target protein. Kishida, S., Shirataki, H., Sasaki, T., Kato, M., Kaibuchi, K., Takai, Y. J. Biol. Chem. (1993) [Pubmed]
  27. NF1 mRNA isoform expression in PC12 cells: modulation by extrinsic factors. Metheny, L.J., Skuse, G.R. Exp. Cell Res. (1996) [Pubmed]
  28. ADP-ribosylation factor-directed GTPase-activating protein. Purification and partial characterization. Makler, V., Cukierman, E., Rotman, M., Admon, A., Cassel, D. J. Biol. Chem. (1995) [Pubmed]
  29. Germ cell beta-chimaerin, a new GTPase-activating protein for p21rac, is specifically expressed during the acrosomal assembly stage in rat testis. Leung, T., How, B.E., Manser, E., Lim, L. J. Biol. Chem. (1993) [Pubmed]
  30. Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells. Hiragun, T., Peng, Z., Beaven, M.A. Mol. Pharmacol. (2005) [Pubmed]
  31. Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf. Ohba, T., Ishino, M., Aoto, H., Sasaki, T. Biochem. J. (1998) [Pubmed]
  32. Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein. Nagano, F., Sasaki, T., Fukui, K., Asakura, T., Imazumi, K., Takai, Y. J. Biol. Chem. (1998) [Pubmed]
  33. Immunohistochemical localization of the INsP4 receptor GTPase-activating protein GAP1IP4BP in the rat brain. Signore, A.P., O'Rourke, F., Lu, X., Feinstein, M.B., Yeh, H.H. J. Neurosci. Res. (1999) [Pubmed]
  34. Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons. Oinuma, I., Katoh, H., Negishi, M. J. Neurosci. (2004) [Pubmed]
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