Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PMEAMT - phosphoethanolamine N-methyltransferase 2

Arabidopsis thaliana

Synonyms: AtPMEAMT, T1N15.23, T1N15_23, phosphoethanolamine N-methyltransferase

Machado, C.R. et al., Boisson, B. et al.

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High impact information on AT1G48600

AtNMT1 compensated for the nmt1 defect in yeast, whereas AtNMT2 and chimeras of the two genes did not [1].
This cDNA presents a high homology to a stress related gene from two species of Fusarium (sti35) and to genes whose products participate in the thiamine biosynthesis pathway, THI4, from Saccharomyces cerevisiae and nmt2 from Schizosaccharomyces pombe [2].

Other interactions of AT1G48600

AtNMT1 is therefore responsible for the A. thaliana N-myristoylome, whereas AtNMT2 does not seem to have usual myristoylation activity [1].

References

Unexpected protein families including cell defense components feature in the N-myristoylome of a higher eukaryote. Boisson, B., Giglione, C., Meinnel, T. J. Biol. Chem. (2003) [Pubmed]
Thi1, a thiamine biosynthetic gene in Arabidopsis thaliana, complements bacterial defects in DNA repair. Machado, C.R., de Oliveira, R.L., Boiteux, S., Praekelt, U.M., Meacock, P.A., Menck, C.F. Plant Mol. Biol. (1996) [Pubmed]

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