The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DEK1  -  calpain-type cysteine protease DEK1

Arabidopsis thaliana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on DEK1

  • The predicted 2,159-aa DEK1 protein has 21 transmembrane regions, an extracellular loop, and a cysteine proteinase domain that shares high homology with domain II of m-calpain from animals [1].
  • Our results not only identify a specific role for AtDEK1 during embryogenesis, but underline the potential key importance of L1 specification at the globular stage for subsequent progression through embryogenesis [2].
  • Loss of AtDEK1 function leads to early embryo lethality characterized by a severe loss of cell organization in the embryo proper and abnormal cell divisions within the suspensor [2].
  • The conclusion that the observed phenotype is caused by a T-DNA insertion in the Arabidopsis DEK1 gene is confirmed by complementation with the Arabidopisis DEK1 genomic sequence, as well as analysis of a second T-DNA insertion allele [3].

Biological context of DEK1

  • Mutation in the Arabidopisis thaliana DEK1 calpain gene perturbs endosperm and embryo development while over-expression affects organ development globally [3].
  • Over-expression of the Arabidopsis DEK1 gene coding sequence under the control of the 35S promoter causes a number of developmental phenotypes, including a global lack of trichomes, leaves exhibiting improper dorsiventral symmetry and aberrant cell organization in flowers [3].

Other interactions of DEK1


Analytical, diagnostic and therapeutic context of DEK1


  1. The defective kernel 1 (dek1) gene required for aleurone cell development in the endosperm of maize grains encodes a membrane protein of the calpain gene superfamily. Lid, S.E., Gruis, D., Jung, R., Lorentzen, J.A., Ananiev, E., Chamberlin, M., Niu, X., Meeley, R., Nichols, S., Olsen, O.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. AtDEK1 is essential for specification of embryonic epidermal cell fate. Johnson, K.L., Degnan, K.A., Ross Walker, J., Ingram, G.C. Plant J. (2005) [Pubmed]
  3. Mutation in the Arabidopisis thaliana DEK1 calpain gene perturbs endosperm and embryo development while over-expression affects organ development globally. Lid, S.E., Olsen, L., Nestestog, R., Aukerman, M., Brown, R.C., Lemmon, B., Mucha, M., Opsahl-Sorteberg, H.G., Olsen, O.A. Planta (2005) [Pubmed]
WikiGenes - Universities