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Gene Review:

LTBP4 - latent transforming growth factor beta...

Homo sapiens

Synonyms: ARCL1C, FLJ46318, FLJ90018, LTBP-4, LTBP-4L, ...

Giltay, R. et al., Hersh, C.P. et al., Koli, K. et al., Chen, Y. et al.

Koli, Saharinen, Kärkkäinen, Keski-Oja, Hersh, Demeo, Lazarus, Celedón, Raby, Benditt, Criner, Make, Martinez, Scanlon, Sciurba, Utz, Reilly, Silverman,

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Disease relevance of LTBP4

Overlapping cDNA clones from human heart and melanoma libraries were used to establish the 1587-residue sequence of a novel protein (LTBP-4) belonging to the family of extracellular microfibrillar proteins which also bind transforming growth factor-beta [1].

High impact information on LTBP4

LTBP-4delta8-Cys3rd does not bind TGF-beta and it was found to be expressed in the same tissues as the full length LTBP-4 [2].
Markers in LTBP4 (p </= 0.05) and SFTPB (p = 0.005) were associated with 6-min walk test distance [3].
In all subjects, single-nucleotide polymorphisms (SNPs) in EPHX1 (p </= 0.03) and in LTBP4 (p </= 0.03) were associated with maximal output on cardiopulmonary exercise testing [3].
We speculated that this difference was due to the substitution of three acidic residues by alanine, serine, and arginine in the LTBP-4 sequence [4].
LTBP-4 consists of 20 EG modules, 17 of them with a consensus sequence for calcium binding, 4 TB modules with 8 cysteines and several proline-rich regions [1].

Physical interactions of LTBP4

The modular structure predicts that LTBP-4 should be a microfibrillar protein which probably also binds TGF-beta [1].

Other interactions of LTBP4

The expression of the non-TGF-beta-binding variant of LTBP-4 may be important for the regulation of TGF-beta deposition in tissues [2].

References

Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins. Giltay, R., Kostka, G., Timpl, R. FEBS Lett. (1997) [Pubmed]
Novel non-TGF-beta-binding splice variant of LTBP-4 in human cells and tissues provides means to decrease TGF-beta deposition. Koli, K., Saharinen, J., Kärkkäinen, M., Keski-Oja, J. J. Cell. Sci. (2001) [Pubmed]
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Hersh, C.P., Demeo, D.L., Lazarus, R., Celedón, J.C., Raby, B.A., Benditt, J.O., Criner, G., Make, B., Martinez, F.J., Scanlon, P.D., Sciurba, F.C., Utz, J.P., Reilly, J.J., Silverman, E.K. Am. J. Respir. Crit. Care Med. (2006) [Pubmed]
Amino acid requirements for formation of the TGF-beta-latent TGF-beta binding protein complexes. Chen, Y., Ali, T., Todorovic, V., O'leary, J.M., Kristina Downing, A., Rifkin, D.B. J. Mol. Biol. (2005) [Pubmed]

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