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Gene Review:

TMM - transmembrane leucine-repeat containing...

Arabidopsis thaliana

Synonyms: AtRLP17, F18B13.16, F18B13_16, Receptor Like Protein 17, TOO MANY MOUTHS

Nadeau, J.A. et al., Geisler, M. et al., Von Groll, U. et al., Shpak, E.D. et al.

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High impact information on TMM

Thus, we propose that SDD1 generates an extracellular signal by meristemoids/guard mother cells and demonstrate that the function of SDD1 is dependent on TMM activity [1].
Our findings suggest that the negative regulation of ER-family RLKs by TMM, which is an LRR receptor-like protein, is critical for proper stomatal differentiation [2].
TMM appears to function in a position-dependent signaling pathway that controls the plane of patterning divisions as well as the balance between stem cell renewal and differentiation in stomatal and epidermal development [3].
TMM encodes a leucine-rich repeat-containing receptor-like protein expressed in proliferative postprotodermal cells [3].

Analytical, diagnostic and therapeutic context of TMM

TMM is thus necessary for two position-dependent events in leaves: the orientation of asymmetric divisions that pattern stomata, and the control of which cells will enter the stomatal pathway [4].

References

The subtilisin-like serine protease SDD1 mediates cell-to-cell signaling during Arabidopsis stomatal development. Von Groll, U., Berger, D., Altmann, T. Plant Cell (2002) [Pubmed]
Stomatal patterning and differentiation by synergistic interactions of receptor kinases. Shpak, E.D., McAbee, J.M., Pillitteri, L.J., Torii, K.U. Science (2005) [Pubmed]
Control of stomatal distribution on the Arabidopsis leaf surface. Nadeau, J.A., Sack, F.D. Science (2002) [Pubmed]
Oriented asymmetric divisions that generate the stomatal spacing pattern in arabidopsis are disrupted by the too many mouths mutation. Geisler, M., Nadeau, J., Sack, F.D. Plant Cell (2000) [Pubmed]

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