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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Terms

 

Gene Review: 

KIAA1804  -  mixed lineage kinase 4

Homo sapiens

Synonyms: MLK4, dJ862P8.3
 
 
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Disease relevance of KIAA1804

 

High impact information on KIAA1804

  • While definitive functions of LRRK2 have yet to be described, the domain structure of LRRK2 suggests that it plays an important role in the regulation of signal transduction cascades through its dual enzymatic activities of GTPase and MAPKKK [3].
  • This large complex protein of 280kDa contains several functional domains including leucine-rich repeats, Ras-related GTPase, mitogen-activated protein kinase kinase kinase (MAPKKK), and WD40 repeats [3].
  • Lrrk2 is a member of the Roc (Ras of complex proteins) family, with Ras GTPase and MAPKKK (mitogen-activated protein kinase kinase kinase) catalytic domains [4].

References

  1. Absence of tyrosine kinase mutations in Japanese colorectal cancer patients. Shao, R.X., Kato, N., Lin, L.J., Muroyama, R., Moriyama, M., Ikenoue, T., Watabe, H., Otsuka, M., Guleng, B., Ohta, M., Tanaka, Y., Kondo, S., Dharel, N., Chang, J.H., Yoshida, H., Kawabe, T., Omata, M. Oncogene (2007) [Pubmed]
  2. Kinase domain mutation of MLK4 gene is uncommon in gastric and hepatocellular carcinomas. Soung, Y.H., Lee, J.W., Kim, S.Y., Nam, S.W., Park, W.S., Lee, J.Y., Yoo, N.J., Lee, S.H. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. (2006) [Pubmed]
  3. Leucine-rich repeat kinase 2: relevance to Parkinson's disease. Guo, L., Wang, W., Chen, S.G. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  4. Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease. Ross, O.A., Farrer, M.J. Biochem. Soc. Trans. (2005) [Pubmed]
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