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Gene Review:

SLC12A8 - solute carrier family 12, member 8

Homo sapiens

Synonyms: CCC9, Cation-chloride cotransporter 9, Solute carrier family 12 member 8

Hüffmeier, U. et al., Hebert, S.C. et al.

Hebert, Mount, Gamba,

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Disease relevance of SLC12A8

Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris [1].

High impact information on SLC12A8

Based on our investigation of the linkage disequilibrium (LD) structure of SLC12A8, we assayed 35 haplotype tag SNP and grouped them into nine LD-blocks [1].
Through extended haplotype analysis, we could show that two independent association signals exist in SLC12A8, suggesting allelic heterogeneity [1].
The transported substrates of the remaining two SLC12 family members, SLC12A8 and SLC12A9, are as yet unknown [2].

References

Systematic linkage disequilibrium analysis of SLC12A8 at PSORS5 confirms a role in susceptibility to psoriasis vulgaris. Hüffmeier, U., Lascorz, J., Traupe, H., Böhm, B., Schürmeier-Horst, F., Ständer, M., Kelsch, R., Baumann, C., Küster, W., Burkhardt, H., Reis, A. J. Invest. Dermatol. (2005) [Pubmed]
Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Hebert, S.C., Mount, D.B., Gamba, G. Pflugers Arch. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP006249	Anopheles gambiae str. PEST
SLC12A8	Bos taurus
F10E7.9	Caenorhabditis elegans
SLC12A8	Canis lupus familiaris
slc12a8	Danio rerio
CG12773	Drosophila melanogaster
SLC12A8	Gallus gallus
SLC12A8	Macaca mulatta
Slc12a8	Mus musculus
SLC12A8	Pan troglodytes
Slc12a8	Rattus norvegicus
LOC100488646	Xenopus (Silurana) tropicalis

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