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Gene Review

SLC12A9  -  solute carrier family 12, member 9

Homo sapiens

Synonyms: CCC-interacting protein 1, CCC6, CIP1, Cation-chloride cotransporter 6, Cation-chloride cotransporter-interacting protein 1, ...
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Disease relevance of SLC12A9


High impact information on SLC12A9


Biological context of SLC12A9

  • In conclusion, ATP, in part, blocked H(2)O(2)-induced increase of p21(WAF1/Cip1) and p27(Kip1) expression through PI3K and Akt signal pathway in renal PTCs [11].
  • Nuclear run-on transcription assays and p21 mRNA half-life studies indicated that iron was required to support transcriptional activation of p21(WAF1/CIP1) after a PMA stimulus [12].
  • Urothelial cells treated with PPARgamma ligands showed drastic morphologic changes and cell cycle arrest at G0/G1 phase accompanied with increased mRNA level of a cyclin-dependent kinase inhibitor p21(WAF1/CIP1) [13].

Anatomical context of SLC12A9


Associations of SLC12A9 with chemical compounds

  • In contrast, ATP increased the level of thymidine, BrdU incorporation (>10(-5) M), and decreased the p21(WAF/Cip1) and p27(Kip1) expression levels, suggesting that ATP has a protective effect against H(2)O(2)-induced oxidative damage [11].
  • Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21(WAF1/Cip1) and p27(Kip1) expression in primary cultured renal proximal tubule cells: Role of PI3K and Akt signaling [11].
  • However, co-transfection of HSV-tk with Cip1/Waf1 encoding the p21(cip1/waf1) inhibitor of cdks, allows 100 microM ganciclovir to eradicate the population of tumor cells [14].

Other interactions of SLC12A9


Analytical, diagnostic and therapeutic context of SLC12A9

  • After the cells reached confluence, total protein was extracted, and the relative expression of p16(INK4a), p21(WAF1/Cip1), and p27(Kip1) was determined by Western blot analysis [10].
  • RESULTS: Immunocytochemistry confirmed the expression and nuclear localization of p16(INK4a), p21(WAF1/Cip1), and p27(Kip1) in HCECs in situ [10].


  1. Detection of p21WAF1/Cip1 in brain metastases. Ruan, S., Fuller, G., Levin, V., Bruner, J.M., Zhang, W. J. Neurooncol. (1998) [Pubmed]
  2. p21/waf1/cip1 in gastric cancer: associations with histopathological subtypes, lymphonodal metastasis, prognosis and p53 status. Baldus, S.E., Schneider, P.M., Mönig, S.P., Zirbes, T.K., Fromm, S., Meyer, W., Glossmann, J., Schüler, S., Thiele, J., Hölscher, A.H., Dienes, H.P. Scand. J. Gastroenterol. (2001) [Pubmed]
  3. Correlation between TGF-beta1 and p21 (WAF1/CIP1) expression and prognosis in resectable invasive ductal carcinoma of the pancreas. Hashimoto, K., Nio, Y., Sumi, S., Toga, T., Omori, H., Itakura, M., Yano, S. Pancreas (2001) [Pubmed]
  4. Downregulation of p21(WAF1/CIP1) and estrogen receptor alpha in MCF-7 cells by antisense oligonucleotides containing locked nucleic acid (LNA). Jepsen, J.S., Pfundheller, H.M., Lykkesfeldt, A.E. Oligonucleotides. (2004) [Pubmed]
  5. p21WAF1/CIP1 gene DNA sequencing and its expression in human osteosarcoma. Liao, W.M., Zhang, C.L., Li, F.B., Zeng, B.F., Zeng, Y.X. Chin. Med. J. (2004) [Pubmed]
  6. Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line. Zhong, W., Oberley, T.D. Cancer Res. (2001) [Pubmed]
  7. Cloning and functional characterization of a cation-Cl- cotransporter-interacting protein. Caron, L., Rousseau, F., Gagnon, E., Isenring, P. J. Biol. Chem. (2000) [Pubmed]
  8. KLF2 inhibits Jurkat T leukemia cell growth via upregulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1. Wu, J., Lingrel, J.B. Oncogene (2004) [Pubmed]
  9. DNA damage and p21(WAF1/CIP1/SDI1) in experimental injury of the rat adrenal cortex and trauma-associated damage of the human adrenal cortex. Didenko, V.V., Wang, X., Yang, L., Hornsby, P.J. J. Pathol. (1999) [Pubmed]
  10. Age differences in cyclin-dependent kinase inhibitor expression and rb hyperphosphorylation in human corneal endothelial cells. Enomoto, K., Mimura, T., Harris, D.L., Joyce, N.C. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  11. Extracellular adenosine triphosphate protects oxidative stress-induced increase of p21(WAF1/Cip1) and p27(Kip1) expression in primary cultured renal proximal tubule cells: Role of PI3K and Akt signaling. Lee, Y.J., Lee, J.H., Han, H.J. J. Cell. Physiol. (2006) [Pubmed]
  12. A new molecular role for iron in regulation of cell cycling and differentiation of HL-60 human leukemia cells: iron is required for transcription of p21(WAF1/CIP1) in cells induced by phorbol myristate acetate. Gazitt, Y., Reddy, S.V., Alcantara, O., Yang, J., Boldt, D.H. J. Cell. Physiol. (2001) [Pubmed]
  13. PPARgamma ligands suppress proliferation of human urothelial basal cells in vitro. Kawakami, S., Arai, G., Hayashi, T., Fujii, Y., Xia, G., Kageyama, Y., Kihara, K. J. Cell. Physiol. (2002) [Pubmed]
  14. The cyclin-dependent kinase inhibitor p21(cip1/waf1) enhances the cytotoxicity of ganciclovir in HSV-tk transfected ovarian carcinoma cells. Ziller, C., Lincet, H., Muller, C.D., Staedel, C., Behr, J.P., Poulain, L. Cancer Lett. (2004) [Pubmed]
  15. Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family. Hebert, S.C., Mount, D.B., Gamba, G. Pflugers Arch. (2004) [Pubmed]
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