Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Hdac3 - histone deacetylase 3

Rattus norvegicus

Synonyms: HD3, Histone deacetylase 3

Dangond, F. et al., Gloss, B. et al.

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High impact information on Hdac3

We found that TRE1 recruits corepressor complexes containing nuclear receptor corepressor and histone deacetylase 3 in the absence of ligand, and steroid receptor coactivator-1-containing coactivator complexes with both T3 and GC-1 [1].
Our results suggest a cell cycle function for murine Hdac3, reflecting the complex regulatory roles of this gene family [2].

Analytical, diagnostic and therapeutic context of Hdac3

Using bioinformatic screening and PCR, we have now cloned the murine Hdac3 cDNA, which encodes a 428-amino-acid protein with near complete identity to its human ortholog [2].

References

Different configurations of specific thyroid hormone response elements mediate opposite effects of thyroid hormone and GC-1 on gene expression. Gloss, B., Giannocco, G., Swanson, E.A., Moriscot, A.S., Chiellini, G., Scanlan, T., Baxter, J.D., Dillmann, W.H. Endocrinology (2005) [Pubmed]
Cloning and expression of a murine histone deacetylase 3 (mHdac3) cDNA and mapping to a region of conserved synteny between murine chromosome 18 and human chromosome 5. Dangond, F., Foerznler, D., Weremowicz, S., Morton, C.C., Beier, D.R., Gullans, S.R. Mol. Cell Biol. Res. Commun. (1999) [Pubmed]

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