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Gene Review

Hdac3  -  histone deacetylase 3

Mus musculus

Synonyms: AW537363, HD3, Histone deacetylase 3
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Disease relevance of Hdac3


High impact information on Hdac3


Biological context of Hdac3


Anatomical context of Hdac3


Other interactions of Hdac3

  • Our observations suggest that the co-repressor CtBP1 and HDAC3 are part of transcription silencing complex that mediates the transcriptional repression by Glis2 [12].


  1. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. Trivedi, C.M., Lu, M.M., Wang, Q., Epstein, J.A. J. Biol. Chem. (2008) [Pubmed]
  2. Regulation of relB in dendritic cells by means of modulated association of vitamin D receptor and histone deacetylase 3 with the promoter. Dong, X., Lutz, W., Schroeder, T.M., Bachman, L.A., Westendorf, J.J., Kumar, R., Griffin, M.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. N-terminal region, C-terminal region, nuclear export signal, and deacetylation activity of histone deacetylase-3 are essential for the viability of the DT40 chicken B cell line. Takami, Y., Nakayama, T. J. Biol. Chem. (2000) [Pubmed]
  4. The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3. Hartman, H.B., Yu, J., Alenghat, T., Ishizuka, T., Lazar, M.A. EMBO Rep. (2005) [Pubmed]
  5. PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner. Fajas, L., Egler, V., Reiter, R., Miard, S., Lefebvre, A.M., Auwerx, J. Oncogene (2003) [Pubmed]
  6. TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3. Wang, L., Hiebert, S.W. Oncogene (2001) [Pubmed]
  7. Assignment of the histone deacetylase gene (Hdac3) to mouse chromosome 18B3 by in situ hybridization. Mahlknecht, U., Bucala, R., Verdin, E. Cytogenet. Cell Genet. (1999) [Pubmed]
  8. Modulation of splicing events in histone deacetylase 3 by various extracellular and signal transduction pathways. Gray, S.G., Iglesias, A.H., Teh, B.T., Dangond, F. Gene Expr. (2003) [Pubmed]
  9. A panel of deleted mouse X chromosome somatic cell hybrids derived from the embryonic stem cell line HD3 shows preferential breakage in the Hprt-DXHX254E region. Arnaud, D., Mattei, M.G., Avner, P. Genomics (1993) [Pubmed]
  10. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Fajas, L., Egler, V., Reiter, R., Hansen, J., Kristiansen, K., Debril, M.B., Miard, S., Auwerx, J. Dev. Cell (2002) [Pubmed]
  11. Hairless contains a novel nuclear matrix targeting signal and associates with histone deacetylase 3 in nuclear speckles. Djabali, K., Christiano, A.M. Differentiation (2004) [Pubmed]
  12. Krüppel-like zinc finger protein Gli-similar 2 (Glis2) represses transcription through interaction with C-terminal binding protein 1 (CtBP1). Kim, S.C., Kim, Y.S., Jetten, A.M. Nucleic Acids Res. (2005) [Pubmed]
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