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Gene Review

Hdac3  -  Histone deacetylase 3

Drosophila melanogaster

Synonyms: CG2128, DHDAC3, DmHDAC3, Dmel\CG2128, Dromel_CG2128_FBtr0078767_hdac3_mORF, ...
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High impact information on Hdac3

  • Consistent with this, recombinant dHDAC1 coimmunoprecipitates with components of the Drosophila NuRD complex and dHDAC3 with an as yet unknown 45-kDa protein [1].
  • A search for other dHDAC3-like genes failed to find other potential paralogues in D. melanogaster, but identified significant homologies with bacterial and fungal genes encoding enzymes that metabolise acetyl groups, and with genes for other hydrolyases such as carboxypeptidase [2].

Biological context of Hdac3


Other interactions of Hdac3

  • These proteins, together with two class I histone deacetylases, dHDAC1 and dHDAC3, have been expressed and characterized as epitope-tagged recombinant proteins in Schneider SL2 cells [1].


  1. dSIR2 and dHDAC6: two novel, inhibitor-resistant deacetylases in Drosophila melanogaster. Barlow, A.L., van Drunen, C.M., Johnson, C.A., Tweedie, S., Bird, A., Turner, B.M. Exp. Cell Res. (2001) [Pubmed]
  2. Molecular cloning of Drosophila melanogaster cDNAs that encode a novel histone deacetylase dHDAC3. Johnson, C.A., Barlow, A.L., Turner, B.M. Gene (1998) [Pubmed]
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