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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PLA2G12B  -  phospholipase A2, group XIIB

Homo sapiens

Synonyms: FKSG71, GXIIB, GXIII sPLA2-like, GXIIIsPLA2, Group XIIB secretory phospholipase A2-like protein, ...
 
 
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Disease relevance of PLA2G12B

  • Recombinant expression of human (hGXIIB) and mouse (mGXIIB) sPLA(2)s in Escherichia coli indicates that GXIIB sPLA(2)s display no measurable lipolytic activity on various types of phospholipid substrates [1].
 

High impact information on PLA2G12B

  • The RNA tissue distribution of GXIIB sPLA(2)s is distinct from that of other sPLA(2)s including the homologous GXIIA [1].
  • Strikingly, the GXIIB sPLA(2) has a mutation in the active site, replacing the canonical histidine by a leucine, suggesting that this sPLA(2) is catalytically inactive [1].
 

Analytical, diagnostic and therapeutic context of PLA2G12B

  • Time-resolved fluoroimmunoassays (TR-FIA) were developed for all human secreted phospholipases A(2) (PLA(2)), viz. group (G) IB, GIIA, GIID, GIIE, GIIF, GIII, GV, GX and GXIIA PLA(2) and the GXIIB PLA(2)-like protein [2].

References

  1. Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity. Rouault, M., Bollinger, J.G., Lazdunski, M., Gelb, M.H., Lambeau, G. Biochemistry (2003) [Pubmed]
  2. Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum. Nevalainen, T.J., Eerola, L.I., Rintala, E., Laine, V.J., Lambeau, G., Gelb, M.H. Biochim. Biophys. Acta (2005) [Pubmed]
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