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Gene Review

MYPN  -  myopalladin

Homo sapiens

Synonyms: 145 kDa sarcomeric protein, CMD1DD, CMH22, MYOP, Myopalladin, ...
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High impact information on MYPN

  • The myopathic changes in the nebulin KO model include depressed contractility, loss of myopalladin from the Z-disk, and dysregulation of genes involved in calcium homeostasis and glycogen metabolism; features potentially relevant for understanding human NM [1].
  • This suggests that palladin and myopalladin may have conserved roles in stress fiber and Z-line assembly [2].
  • The NH(2)-terminal region of myopalladin specifically binds to the cardiac ankyrin repeat protein (CARP), a nuclear protein involved in control of muscle gene expression [2].
  • The palladin/myotilin/myopalladin family of actin-associated scaffolds [3].

Anatomical context of MYPN


Physical interactions of MYPN

  • Of the six peptides studied, PR2 of titin (VPEKKAPVAPPK) and myopalladin MyoP2 (646VKEPPPVLAKPK657) bind to nebulin SH3 with micromolar affinity (approximately 31 and 3.4 microM, respectively), whereas the other four peptides bind weakly (>100 microM) [4].


  1. Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. Witt, C.C., Burkart, C., Labeit, D., McNabb, M., Wu, Y., Granzier, H., Labeit, S. EMBO J. (2006) [Pubmed]
  2. Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. Bang, M.L., Mudry, R.E., McElhinny, A.S., Trombitás, K., Geach, A.J., Yamasaki, R., Sorimachi, H., Granzier, H., Gregorio, C.C., Labeit, S. J. Cell Biol. (2001) [Pubmed]
  3. The palladin/myotilin/myopalladin family of actin-associated scaffolds. Otey, C.A., Rachlin, A., Moza, M., Arneman, D., Carpen, O. Int. Rev. Cytol. (2005) [Pubmed]
  4. Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin. Ma, K., Wang, K. FEBS Lett. (2002) [Pubmed]
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