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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PLEKHA8  -  pleckstrin homology domain containing,...

Homo sapiens

Synonyms: FAPP-2, FAPP2, MGC3358, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, ...
 
 
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High impact information on PLEKHA8

  • We have identified two effectors of PtdIns(4)P, the four-phosphate-adaptor protein 1 and 2 (FAPP1 and FAPP2) [1].
  • We have analyzed the role of the phosphatidylinositol-4-phosphate adaptor protein-2 (FAPP2), a component of the apical transport machinery, in cilium formation in polarized Madin-Darby canine kidney (MDCK) cells [2].
  • Furthermore, by using fluorescence recovery after photobleaching studies of domain connectivity and the generalized polarization spectra of Laurdan, we demonstrate that FAPP2 depletion impairs the formation of condensed apical membrane domains [2].
 

Anatomical context of PLEKHA8

  • From the Cover: FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells [2].

References

  1. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Godi, A., Di Campli, A., Konstantakopoulos, A., Di Tullio, G., Alessi, D.R., Kular, G.S., Daniele, T., Marra, P., Lucocq, J.M., De Matteis, M.A. Nat. Cell Biol. (2004) [Pubmed]
  2. From the Cover: FAPP2, cilium formation, and compartmentalization of the apical membrane in polarized Madin-Darby canine kidney (MDCK) cells. Vieira, O.V., Gaus, K., Verkade, P., Fullekrug, J., Vaz, W.L., Simons, K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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