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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Photobleaching

 
 
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Disease relevance of Photobleaching

 

High impact information on Photobleaching

  • Fluorescence recovery after photobleaching of the actin comet tails revealed that endocytic complexes are nucleation sites for rapid actin polymerization [6].
  • Regeneration of rod visual pigments after photobleaching requires a protein called Rpe65 [7].
  • Here we record an intersubunit rotation in real time in the functional enzyme by applying polarized absorption relaxation after photobleaching to immobilized F1 with eosin-labelled gamma [8].
  • We report here a direct determination of the human cone pigment photobleaching difference absorption spectra after the production of each cone pigment apoprotein in tissue culture cells transfected with the corresponding complementary DNA clones [9].
  • The method used extends the FRAP procedure (fluorescence redistribution after photobleaching) to bacteria and the results demonstrate rapid diffusion of lipopolysaccharide (D = 2.0 +/- 0.9 x 10(-10) cm2s-1) over micrometre distances [10].
 

Chemical compound and disease context of Photobleaching

 

Biological context of Photobleaching

 

Anatomical context of Photobleaching

 

Associations of Photobleaching with chemical compounds

  • Two-photon photobleaching and photorelease of fluorescein dextran were used to generate concentration gradients between spines and shafts in rat CA1 pyramidal neurons [26].
  • In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth [27].
  • Relatively selective removal of bilirubin from the plasma by photobleaching normalized the decreased PMA in five jaundiced patients but produced no apparent change in five normal subjects [28].
  • Fluorescence photobleaching recovery was used to measure the lateral mobility of two integral membrane proteins, glycophorin and band 3, and two lipid analogues, fluorescein phosphatidylethanolamine (Fl-PE) and carbocyanine dyes, in RBCs and ghosts adherent to schistosomula [29].
  • Photobleaching/recovery analysis revealed that the luminal segment determines restricted diffusion and immobility of the protein [30].
 

Gene context of Photobleaching

  • Photobleaching experiments reveal that MDM2 and VHL are highly mobile proteins in settings where their substrates are efficiently degraded [31].
  • Here, we studied the interaction of Brd4 with chromatin in living cells by photobleaching [32].
  • Photobleaching and tracking of replication foci revealed a dynamic equilibrium between two kinetic pools of PCNA, i.e., bound to replication foci and as a free mobile fraction [33].
  • Fluorescence recovery after photobleaching experiments revealed that Bach2 showed rapid turnover in the nuclear foci [34].
  • Photobleaching experiments revealed that SUMO-1 dynamics was much slower than SUMO-2 and -3 dynamics [35].
 

Analytical, diagnostic and therapeutic context of Photobleaching

References

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