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Chemical Compound Review

AC1OAGGW     (2R)-2-[[hydroxy- [(2R,3S,5R,6R)-2,3,5,6...

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Disease relevance of Phosphatidylinositol 4-phosphate


Psychiatry related information on Phosphatidylinositol 4-phosphate


High impact information on Phosphatidylinositol 4-phosphate


Chemical compound and disease context of Phosphatidylinositol 4-phosphate


Biological context of Phosphatidylinositol 4-phosphate


Anatomical context of Phosphatidylinositol 4-phosphate


Associations of Phosphatidylinositol 4-phosphate with other chemical compounds


Gene context of Phosphatidylinositol 4-phosphate


Analytical, diagnostic and therapeutic context of Phosphatidylinositol 4-phosphate


  1. The Friedreich's ataxia gene encodes a novel phosphatidylinositol-4- phosphate 5-kinase. Carvajal, J.J., Pook, M.A., dos Santos, M., Doudney, K., Hillermann, R., Minogue, S., Williamson, R., Hsuan, J.J., Chamberlain, S. Nat. Genet. (1996) [Pubmed]
  2. 1-Phosphatidylinositol 4-phosphate 5-kinase (EC a proliferation- and malignancy-linked signal transduction enzyme. Singhal, R.L., Prajda, N., Yeh, Y.A., Weber, G. Cancer Res. (1994) [Pubmed]
  3. A phosphotransferase that generates phosphatidylinositol 4-phosphate (PtdIns-4-P) from phosphatidylinositol and lipid A in Rhizobium leguminosarum. A membrane-bound enzyme linking lipid a and ptdins-4-p biosynthesis. Basu, S.S., York, J.D., Raetz, C.R. J. Biol. Chem. (1999) [Pubmed]
  4. EBV increases phosphoinositide kinase activities in human B cells. Suzuki, Y., Ohsugi, K., Ono, Y. J. Immunol. (1992) [Pubmed]
  5. Brain polyphosphoinositide metabolism during focal ischemia in rat cortex. Lin, T.N., Liu, T.H., Xu, J., Hsu, C.Y., Sun, G.Y. Stroke (1991) [Pubmed]
  6. Screening of PIP5K2A promoter region for mutations in bipolar disorder and schizophrenia. Stopkova, P., Vevera, J., Paclt, I., Zukov, I., Papolos, D.F., Saito, T., Lachman, H.M. Psychiatr. Genet. (2005) [Pubmed]
  7. Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Honda, A., Nogami, M., Yokozeki, T., Yamazaki, M., Nakamura, H., Watanabe, H., Kawamoto, K., Nakayama, K., Morris, A.J., Frohman, M.A., Kanaho, Y. Cell (1999) [Pubmed]
  8. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Chong, L.D., Traynor-Kaplan, A., Bokoch, G.M., Schwartz, M.A. Cell (1994) [Pubmed]
  9. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Auger, K.R., Serunian, L.A., Soltoff, S.P., Libby, P., Cantley, L.C. Cell (1989) [Pubmed]
  10. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. Di Paolo, G., Pellegrini, L., Letinic, K., Cestra, G., Zoncu, R., Voronov, S., Chang, S., Guo, J., Wenk, M.R., De Camilli, P. Nature (2002) [Pubmed]
  11. Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells. Martelli, A.M., Gilmour, R.S., Bertagnolo, V., Neri, L.M., Manzoli, L., Cocco, L. Nature (1992) [Pubmed]
  12. Modulation of phosphoinositide metabolism by pathogenic bacteria. Hilbi, H. Cell. Microbiol. (2006) [Pubmed]
  13. Effects of perphenazine on the metabolism of inositol phospholipids in SK-N-BE(2) human neuroblastoma cells. Pacini, L., Limatola, C., Palma, E., Spinedi, A. Biochem. Pharmacol. (1994) [Pubmed]
  14. Discrete subcellular localization of phosphoinositidase C beta, gamma and delta in PC12 rat pheochromocytoma cells. Mazzoni, M., Bertagnolo, V., Neri, L.M., Carini, C., Marchisio, M., Milani, D., Manzoli, F.A., Capitani, S. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  15. Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation. Jolles, J., Zwiers, H., van Dongen, C.J., Schotman, P., Wirtz, K.W., Gispen, W.H. Nature (1980) [Pubmed]
  16. Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles. Guo, J., Wenk, M.R., Pellegrini, L., Onofri, F., Benfenati, F., De Camilli, P. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells. Olsen, H.L., Hoy, M., Zhang, W., Bertorello, A.M., Bokvist, K., Capito, K., Efanov, A.M., Meister, B., Thams, P., Yang, S.N., Rorsman, P., Berggren, P.O., Gromada, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  18. Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion. Gong, L.W., Di Paolo, G., Diaz, E., Cestra, G., Diaz, M.E., Lindau, M., De Camilli, P., Toomre, D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  19. Transient and sustained increases in inositol 1,4,5-trisphosphate precede the differential growth response in gravistimulated maize pulvini. Perera, I.Y., Heilmann, I., Boss, W.F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  20. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Whitman, M., Downes, C.P., Keeler, M., Keller, T., Cantley, L. Nature (1988) [Pubmed]
  21. Phosphoinositides and the golgi complex. De Matteis, M., Godi, A., Corda, D. Curr. Opin. Cell Biol. (2002) [Pubmed]
  22. Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p. Faulhammer, F., Konrad, G., Brankatschk, B., Tahirovic, S., Knödler, A., Mayinger, P. J. Cell Biol. (2005) [Pubmed]
  23. Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. Brown, F.D., Rozelle, A.L., Yin, H.L., Balla, T., Donaldson, J.G. J. Cell Biol. (2001) [Pubmed]
  24. Aggregation-dependent, integrin-mediated increases in cytoskeletally associated PtdInsP2 (4,5) levels in human platelets are controlled by translocation of PtdIns 4-P 5-kinase C to the cytoskeleton. Hinchliffe, K.A., Irvine, R.F., Divecha, N. EMBO J. (1996) [Pubmed]
  25. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. Mitra, P., Zhang, Y., Rameh, L.E., Ivshina, M.P., McCollum, D., Nunnari, J.J., Hendricks, G.M., Kerr, M.L., Field, S.J., Cantley, L.C., Ross, A.H. J. Cell Biol. (2004) [Pubmed]
  26. Evidence from two transformed cell lines that the phosphorylations of peptide tyrosine and phosphatidylinositol are catalyzed by different proteins. MacDonald, M.L., Kuenzel, E.A., Glomset, J.A., Krebs, E.G. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  27. Polylysine-containing peptides, including the carboxyl-terminal segment of the human c-Ki-ras 2 protein, affect the activity of some key membrane enzymes. Gatica, M., Allende, C.C., Antonelli, M., Allende, J.E. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  28. Coupled inositide phosphorylation and phospholipase D activation initiates clathrin-coat assembly on lysosomes. Arneson, L.S., Kunz, J., Anderson, R.A., Traub, L.M. J. Biol. Chem. (1999) [Pubmed]
  29. Interaction of protein kinase C isozymes with phosphatidylinositol 4,5-bisphosphate. Huang, F.L., Huang, K.P. J. Biol. Chem. (1991) [Pubmed]
  30. Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. Gary, J.D., Wurmser, A.E., Bonangelino, C.J., Weisman, L.S., Emr, S.D. J. Cell Biol. (1998) [Pubmed]
  31. Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Foti, M., Audhya, A., Emr, S.D. Mol. Biol. Cell (2001) [Pubmed]
  32. MSS4, a phosphatidylinositol-4-phosphate 5-kinase required for organization of the actin cytoskeleton in Saccharomyces cerevisiae. Desrivières, S., Cooke, F.T., Parker, P.J., Hall, M.N. J. Biol. Chem. (1998) [Pubmed]
  33. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. Castellino, A.M., Parker, G.J., Boronenkov, I.V., Anderson, R.A., Chao, M.V. J. Biol. Chem. (1997) [Pubmed]
  34. Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase Igamma b. Powner, D.J., Payne, R.M., Pettitt, T.R., Giudici, M.L., Irvine, R.F., Wakelam, M.J. J. Cell. Sci. (2005) [Pubmed]
  35. Characterization of a Rac1- and RhoGDI-associated lipid kinase signaling complex. Tolias, K.F., Couvillon, A.D., Cantley, L.C., Carpenter, C.L. Mol. Cell. Biol. (1998) [Pubmed]
  36. Coated vesicles contain a phosphatidylinositol kinase. Campbell, C.R., Fishman, J.B., Fine, R.E. J. Biol. Chem. (1985) [Pubmed]
  37. Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase. Nakagawa, T., Goto, K., Kondo, H. J. Biol. Chem. (1996) [Pubmed]
  38. Effect of ethanol on rat brain polyphosphoinositides. Shah, I.R., Uma, S., Ramakrishnan, C.V., Hauser, G. J. Neurochem. (1984) [Pubmed]
  39. Characterization of putative polyphosphoinositide binding motifs from phospholipase C beta 2. Simões, A.P., Reed, J., Schnabel, P., Camps, M., Gierschik, P. Biochemistry (1995) [Pubmed]
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