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Gene Review

PLEKHA3  -  pleckstrin homology domain containing,...

Homo sapiens

Synonyms: FAPP-1, FAPP1, PH domain-containing family A member 3, Phosphatidylinositol-four-phosphate adapter protein 1, Phosphoinositol 4-phosphate adapter protein 1, ...
 
 
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High impact information on PLEKHA3

  • We have identified two effectors of PtdIns(4)P, the four-phosphate-adaptor protein 1 and 2 (FAPP1 and FAPP2) [1].
  • The transport of apical cargo from the Golgi was shown to be specifically decreased by adenovirus-mediated RNA interference directed against PI(4)P adaptor protein (FAPP) 2 [2].
  • The PH domains of OSBP and FAPP1 fused to GFP were used to monitor PI(4)P distribution in COS-7 cells during manipulations of PI 4-kinase (PI4K) activities [3].
  • The pp5644-interacting protein FAPP1 (phosphatidylinositol-four-phosphate adaptor protein1) associated protein-1, called FASP1, was obtained by using yeast two-hybrid system [4].
  • The Golgi localization of the PH domain of FAPP1 (four-phosphate-adaptor protein 1), which binds to phosphatidylinositol 4-phosphate, was unaffected [5].
 

Anatomical context of PLEKHA3

References

  1. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Godi, A., Di Campli, A., Konstantakopoulos, A., Di Tullio, G., Alessi, D.R., Kular, G.S., Daniele, T., Marra, P., Lucocq, J.M., De Matteis, M.A. Nat. Cell Biol. (2004) [Pubmed]
  2. FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. Vieira, O.V., Verkade, P., Manninen, A., Simons, K. J. Cell Biol. (2005) [Pubmed]
  3. A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1. Balla, A., Tuymetova, G., Tsiomenko, A., Várnai, P., Balla, T. Mol. Biol. Cell (2005) [Pubmed]
  4. P5644 interacts with phosphatidylinositol-4-phosphate adaptor protein-1 associated protein-1. Ye, X.X., Lu, H., Yu, Y., Ding, N., Zhang, N.L., Huo, K.K., Wan, D.F., Li, Y.Y., Gu, J.R. Mol. Cell. Biochem. (2005) [Pubmed]
  5. High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate. O'Callaghan, D.W., Haynes, L.P., Burgoyne, R.D. Biochem. J. (2005) [Pubmed]
 
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