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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

FBXO18  -  F-box protein, helicase, 18

Homo sapiens

Synonyms: F-box DNA helicase 1, F-box only protein 18, FBH1, FBX18, FLJ14590, ...
 
 
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High impact information on FBXO18

  • However, FBH1(-)(/)(-) cells exhibit increases in both sister chromatid exchange and the formation of radial structures between homologous chromosomes without showing a defect in homologous recombination [1].
  • This phenotype is reminiscent of BLM(-)(/)(-) cells and suggests that Fbh1 may be involved in preventing extensive strand exchange during homologous recombination [1].
  • In addition, disruption of RAD54, a major homologous recombination factor in FBH1(-)(/)(-) cells, results in a marked increase in chromosome-type breaks (breaks on both sister chromatids at the same place) following replication fork arrest [1].
  • Recombinant hFBH1, containing glutathione S-transferase at the N terminus, was expressed in Sf9 cells and purified [2].

References

  1. Cooperative Roles of Vertebrate Fbh1 and Blm DNA Helicases in Avoidance of Crossovers during Recombination Initiated by Replication Fork Collapse. Kohzaki, M., Hatanaka, A., Sonoda, E., Yamazoe, M., Kikuchi, K., Vu Trung, N., Szüts, D., Sale, J.E., Shinagawa, H., Watanabe, M., Takeda, S. Mol. Cell. Biol. (2007) [Pubmed]
  2. The novel human DNA helicase hFBH1 is an F-box protein. Kim, J., Kim, J.H., Lee, S.H., Kim, D.H., Kang, H.Y., Bae, S.H., Pan, Z.Q., Seo, Y.S. J. Biol. Chem. (2002) [Pubmed]
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