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Gene Review

HMRA2  -  Hmra2p

Saccharomyces cerevisiae S288c

Synonyms: MATa2 protein, Silenced mating-type protein A2, YCR096C, YCR96C
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High impact information on HMRA2

  • It has been suggested that STA1 is regulated by MATa2 (I. Yamashita, Y. Takano, and S. Fukui, J. Bacteriol. 164:769-773, 1985), which is a MAT transcript of previously unknown function [1].
  • Therefore, MAT switches occur in MAT alpha/mata-2 HO/ho cells to produce MAT alpha/Mata cells capable of sporulation [2].
  • The MAT alpha/mata-2 diploids do not sporulate [2].
  • MATA2 contains a HMG box with homology to other mating-type genes [3].

Analytical, diagnostic and therapeutic context of HMRA2

  • Northern blot analysis revealed that the MATa2-mediated repression occurs at the posttranscriptional level [4].


  1. Regulation of STA1 gene expression by MAT during the life cycle of Saccharomyces cerevisiae. Dranginis, A.M. Mol. Cell. Biol. (1989) [Pubmed]
  2. Switching of a mating-type a mutant allele in budding yeast Saccharomyces cerevisiae. Klar, A.J., Fogel, S., Radin, D.N. Genetics (1979) [Pubmed]
  3. The MATA locus of the dimorphic yeast Yarrowia lipolytica consists of two divergently oriented genes. Kurischko, C., Schilhabel, M.B., Kunze, I., Franzl, E. Mol. Gen. Genet. (1999) [Pubmed]
  4. Control of STA1 gene expression by the mating-type locus in yeasts. Yamashita, I., Takano, Y., Fukui, S. J. Bacteriol. (1985) [Pubmed]
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