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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Fungal

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Disease relevance of Genes, Fungal


High impact information on Genes, Fungal

  • Other Htz1-activated genes flank the silent HMR mating-type locus [6].
  • Yeast SIR2 is a NAD+-dependent histone deacetylase required for heterochromatic silencing at telomeres, rDNA, and mating-type loci [7].
  • Using a yeast heat shock gene flanked by mating-type silencers as a model system, we find that repressive, SIR-generated heterochromatin is permissive to the constitutive binding of an activator, HSF, and two components of the preinitiation complex (PIC), TBP and Pol II [8].
  • Here, we show that Sir3p is released from telomeres in response to DNA double-strand breaks (DSBs), binds to DSBs, and mediates their repair, independent of cell mating type [9].
  • We have now found that the clr4 gene, which is essential for silencing of centromeres and the mating-type loci in Schizosaccharomyces pombe, encodes a protein with high homology to the product of Su(var)3-9, a gene affecting PEV in Drosophila [10].

Biological context of Genes, Fungal

  • Thus, while it is clear that IME1 is a necessary positive regulator of meiosis, responding both to mating type and nutritional conditions, it is not clear if it is sufficient [11].
  • This human homeobox protein was shown to bind the same DNA sequence as the homeobox domains of the yeast mating type proteins and Drosophila homeotic protein, suggesting that homeobox proteins may have closely related DNA binding characteristics [12].
  • Cell division yields a mother cell, which is competent to transcribe the HO gene and switch mating type, and a daughter cell, which is not [13].
  • A portion of the conserved protein domain present in ftz and several homoeotic genes resembles the DNA-binding region of prokaryotic DNA-binding proteins, and is also similar to products of the yeast mating-type locus [14].
  • Here, we show that distinct site-specific histone H3 methylation patterns define euchromatic and heterochromatic chromosomal domains within a 47-kilobase region of the mating-type locus in fission yeast [15].

Anatomical context of Genes, Fungal


Associations of Genes, Fungal with chemical compounds

  • Electrophoretic analysis on SDS polyacrylamide gel revealed no significant difference in polypeptide patterns of the particles from the two complementary mating types [21].
  • We obtained transgenic potato plants expressing a fungal gene encoding glucose oxidase, which generates H2O2 when glucose is oxidized [22].
  • Activity is in some cases dependent upon the particular A alpha mating type of the recipient [23].
  • Conjugation in Blepharisma japonicum is induced by interaction between complementary mating-types I and II, which excrete blepharmone (gamone 1) and blepharismone (gamone 2), respectively [24].
  • By introducing a thiamine repressible promoter upstream of the mat1 locus, we can force transcription through the imprinted region, erasing the imprint and inhibiting further mating-type switching, in a reversible manner [25].

Gene context of Genes, Fungal

  • Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast [26].
  • The SIR2, SIR3, and SIR4 proteins are required for silencing of transcription at the silent mating type loci and at telomeres in yeast [27].
  • Deletion and overexpression of ASH1 cause reciprocal cell fate transformations: im ash1delta strains, daughters switch mating type as efficiently as mothers [13].
  • SIR1, one of several genes required for repression of yeast silent mating type loci, has a unique role in repression of the HML alpha locus [28].
  • Previous studies have demonstrated a direct role for RAP1 in silencing at HM mating-type loci and telomeres [29].

Analytical, diagnostic and therapeutic context of Genes, Fungal

  • Consistent with the idea that San1 participates as an accessory factor to regulate silent chromatin, including the silent mating-type loci, microarray analysis defined a small but statistically significant role for San1 in transcription of several mating pheromone-responsive genes [30].
  • Under the hypothesis that the conA receptor may be a mating type receptor, we have used this ligand-induced differential cytoskeletal association, in conjunction with electrophoresis and Western blotting, to identify a glycoprotein with an apparent molecular weight (MW) of 23,000 D which may be a mating type receptor [31].
  • PCR analysis with primers specific for genes in the MATa or MATalpha mating-type loci revealed that serotype AD strains are heterozygous for the mating-type locus [32].
  • In tetrad dissection of prototrophic diploids that were obtained by rare mating of hml alpha-1 mutants with a heterothallic strain having the MATa ho HMRa HMLa genotype, many mating-deficient haploid segregants were found, while alpha mating-type segregants were observed in a similar diploid using an hml alpha-2 mutant [33].
  • Using cDNA array profiling, we compared the levels of expression of fungal genes corresponding to approximately 1,200 expressed sequenced tags in the ectomycorrhizal root tips (ECM) and the connected extraradical mycelium (EM) for the Paxillus involutus-Betula pendula ectomycorrhizal association grown on peat in a microcosm system [34].


  1. Interaction between ABO blood groups and ADA genetic polymorphism during intrauterine life. A comparative analysis of couples with habitual abortion and normal puerperae delivering a live-born infant. Lucarini, N., Nicotra, M., Gloria-Bottini, F., Borgiani, P., Amante, A., Muttinelli, C., Signoretti, F., La Torre, M., Bottini, E. Hum. Genet. (1995) [Pubmed]
  2. Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer. Leung, W.K., Yu, J., Bai, A.H., Chan, M.W., Chan, K.K., To, K.F., Chan, F.K., Ng, E.K., Chung, S.C., Sung, J.J. Mol. Carcinog. (2003) [Pubmed]
  3. MHC and non-MHC genetic influences on Rous sarcoma metastasis in chickens. Collins, W.M., Brown, D.W., Ward, P.H., Dunlop, W.R., Briles, W.E. Immunogenetics (1985) [Pubmed]
  4. Disseminated cryptococcosis in an AIDS patient caused by a canavanine-resistant strain of Cryptococcus neoformans var. grubii. Khan, Z.U., Al-Anezi, A.A., Chandy, R., Xu, J. J. Med. Microbiol. (2003) [Pubmed]
  5. Adult-onset GM2 gangliosidosis diagnosed in a fetus. Navon, R., Sandbank, U., Frisch, A., Baram, D., Adam, A. Prenat. Diagn. (1986) [Pubmed]
  6. Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Meneghini, M.D., Wu, M., Madhani, H.D. Cell (2003) [Pubmed]
  7. Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Rosenberg, M.I., Parkhurst, S.M. Cell (2002) [Pubmed]
  8. Silenced chromatin is permissive to activator binding and PIC recruitment. Sekinger, E.A., Gross, D.S. Cell (2001) [Pubmed]
  9. MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Mills, K.D., Sinclair, D.A., Guarente, L. Cell (1999) [Pubmed]
  10. The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Ivanova, A.V., Bonaduce, M.J., Ivanov, S.V., Klar, A.J. Nat. Genet. (1998) [Pubmed]
  11. Dual regulation of meiosis in yeast. Malone, R.E. Cell (1990) [Pubmed]
  12. A human protein specific for the immunoglobulin octamer DNA motif contains a functional homeobox domain. Ko, H.S., Fast, P., McBride, W., Staudt, L.M. Cell (1988) [Pubmed]
  13. Identification of asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene. Sil, A., Herskowitz, I. Cell (1996) [Pubmed]
  14. Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins. Laughon, A., Scott, M.P. Nature (1984) [Pubmed]
  15. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries. Noma K, n.u.l.l., Allis, C.D., Grewal, S.I. Science (2001) [Pubmed]
  16. Cell cycle regulation of SW15 is required for mother-cell-specific HO transcription in yeast. Nasmyth, K., Seddon, A., Ammerer, G. Cell (1987) [Pubmed]
  17. A new yeast PUF family protein, Puf6p, represses ASH1 mRNA translation and is required for its localization. Gu, W., Deng, Y., Zenklusen, D., Singer, R.H. Genes Dev. (2004) [Pubmed]
  18. Cyclic AMP functions as a primary sexual signal in gametes of Chlamydomonas reinhardtii. Pasquale, S.M., Goodenough, U.W. J. Cell Biol. (1987) [Pubmed]
  19. Gametic differentiation in Chlamydomonas reinhardtii. III. Cell wall lysis and microfilament-associated mating structure activation in wild-type and mutant strains. Goodenough, U.W., Weiss, R.L. J. Cell Biol. (1975) [Pubmed]
  20. Effects of glucose repression of the transmission and recombination of mitochondrial genes in yeast (Saccharomyces cerevisiae). Birky, C.W. Genetics (1975) [Pubmed]
  21. Mating-reactive membrane vesicles from cilia of Paramecium caudatum. Kitamura, A., Hiwatashi, K. J. Cell Biol. (1976) [Pubmed]
  22. Disease resistance conferred by expression of a gene encoding H2O2-generating glucose oxidase in transgenic potato plants. Wu, G., Shortt, B.J., Lawrence, E.B., Levine, E.B., Fitzsimmons, K.C., Shah, D.M. Plant Cell (1995) [Pubmed]
  23. Functional analysis of the homeodomain-related proteins of the A alpha locus of Schizophyllum commune. Specht, C.A., Stankis, M.M., Giasson, L., Novotny, C.P., Ullrich, R.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  24. Identification, characterization, and complete amino acid sequence of the conjugation-inducing glycoprotein (blepharmone) in the ciliate Blepharisma japonicum. Sugiura, M., Harumoto, T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  25. Molecular and cellular dissection of mating-type switching steps in Schizosaccharomyces pombe. Holmes, A.M., Kaykov, A., Arcangioli, B. Mol. Cell. Biol. (2005) [Pubmed]
  26. Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast. Nasmyth, K., Stillman, D., Kipling, D. Cell (1987) [Pubmed]
  27. A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. Moazed, D., Johnson, D. Cell (1996) [Pubmed]
  28. Epigenetic inheritance of transcriptional states in S. cerevisiae. Pillus, L., Rine, J. Cell (1989) [Pubmed]
  29. Action of a RAP1 carboxy-terminal silencing domain reveals an underlying competition between HMR and telomeres in yeast. Buck, S.W., Shore, D. Genes Dev. (1995) [Pubmed]
  30. Sir Antagonist 1 (San1) is a ubiquitin ligase. Dasgupta, A., Ramsey, K.L., Smith, J.S., Auble, D.T. J. Biol. Chem. (2004) [Pubmed]
  31. Concanavalin A binding induces association of possible mating-type receptors with the cytoskeleton in Tetrahymena. Pagliaro, L., Wolfe, J. Exp. Cell Res. (1987) [Pubmed]
  32. Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. Lengeler, K.B., Cox, G.M., Heitman, J. Infect. Immun. (2001) [Pubmed]
  33. Mating-type differentiation by transposition of controlling elements in Saccharomyces cerevisiae. Oshima, T., Takano, I. Genetics (1981) [Pubmed]
  34. Identification of genes differentially expressed in extraradical mycelium and ectomycorrhizal roots during Paxillus involutus-Betula pendula ectomycorrhizal symbiosis. Morel, M., Jacob, C., Kohler, A., Johansson, T., Martin, F., Chalot, M., Brun, A. Appl. Environ. Microbiol. (2005) [Pubmed]
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