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Gene Review

ORC3  -  origin recognition complex subunit 3

Saccharomyces cerevisiae S288c

Synonyms: L1365, OAF1, OIF1, Origin recognition complex 62 kDa subunit, Origin recognition complex subunit 3, ...
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High impact information on ORC3

  • We demonstrate through both immunoprecipitation and two-hybrid assays that a domain comprising the first 296 aa of Dbf4p interacts with Orc2p and Orc3p subunits of the origin recognition complex (ORC) [1].
  • In addition, the OAF1 gene product tagged with the hemagglutinin antigen epitope binds to a DNA affinity column containing covalently linked tandem repeats of an essential origin element [2].
  • Murine ORC3 protein contains a putative nuclear localization signal and a non-basic helix-loop-helix motif [3].
  • Transcription of ORC3 is not suppressed in mouse NIH3T3 fibroblasts made quiescent by serum starvation [3].
  • The transcription level of the ORC3 gene is constantly high in all phases of the cell cycle [3].


  1. An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Duncker, B.P., Shimada, K., Tsai-Pflugfelder, M., Pasero, P., Gasser, S.M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Hardy, C.F. Mol. Cell. Biol. (1996) [Pubmed]
  3. Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Springer, J., Nanda, I., Hoehn, K., Schmid, M., Grummt, F. Cytogenet. Cell Genet. (1999) [Pubmed]
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