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Gene Review

OST4  -  Ost4p

Saccharomyces cerevisiae S288c

Synonyms: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4, OTase 4 kDa subunit, Oligosaccharyl transferase 4 kDa subunit, Oligosaccharyl transferase subunit OST4, YDL232W
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High impact information on OST4

  • The residues critical for the OT activity and the stability of Stt3p-Ost4p-Ost3p subcomplex are located in helix alpha2, the larger cytosolic half of this kinked helix [1].
  • To learn where this region of Ost4p is situated in relation to the faces of endoplasmic reticulum (ER) membrane, we determined the membrane topology of Ost4p using an in vivo method and established that it is an Nlumen-Ccyto, type I membrane protein [2].
  • Introduction of Lys or Asp residues at other positions in the putative transmembrane domain or at the N or C terminus of Ost4p had no effect on disrupting subunit interactions or impairing the activity of OT [3].
  • This analysis indicated that when single amino acid residues in a region close to the luminal face of the putative transmembrane domain of Ost4p were changed into an ionizable amino acid such as Lys or Asp, growth at 37 degrees C and OT activity measured in vitro were impaired [3].
  • Stt3p and Ost4p were previously identified in screens for gene products involved in N-linked glycosylation [4].

Biological context of OST4


Associations of OST4 with chemical compounds

  • Here we describe the phenotypic characterization of ost4, a vanadate-resistant mutant that is defective in oligosaccharyltransferase (OTase) activity both in vivo and in vitro [5].

Other interactions of OST4

  • The highly conserved Stt3 protein is a subunit of the yeast oligosaccharyltransferase and forms a subcomplex with Ost3p and Ost4p [4].

Analytical, diagnostic and therapeutic context of OST4


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