The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ELM1  -  Elm1p

Saccharomyces cerevisiae S288c

Synonyms: Serine/threonine-protein kinase ELM1, YKL048C, YKL261
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on ELM1

  • These results demonstrate that the Elm1 kinase plays an important role in G(1) events required for bud emergence and septin organization [1].
  • We found that inhibition of Elm1 kinase activity during G(2) results in a phenotype similar to the phenotype caused by deletion of the ELM1 gene, as expected [1].
  • However, inhibition of Elm1 kinase activity earlier in the cell cycle results in a prolonged G(1) delay [1].
  • In budding yeast, the Elm1 kinase is required for coordination of cell growth and cell division at G(2)/M [1].
  • Previous studies have suggested that Elm1 may function to negatively regulate the Swe1 kinase [2].

Biological context of ELM1

  • Cells carrying a deletion of the ELM1 gene undergo a prolonged mitotic delay, fail to negatively regulate polar bud growth during mitosis, and show defects in septin organization [2].
  • Deletion of ELM1 does not give an snf- phenotype [3].
  • We propose a model in which the Elm1 kinase functions in a mitotic signaling network that controls events required for normal bud growth and cytokinesis, while the Swe1 kinase functions in a checkpoint pathway that delays nuclear division in response to defects in these events [2].
  • Elm1p also activated the purified SNF1 complex, and this correlated with phosphorylation of Thr210 in the activation loop [3].
  • A 'signal integration' model for the complex relationship of Elm1 and the RAS/cAMP pathway in controlling morphogenesis in response to nutrients is proposed [4].

Anatomical context of ELM1

  • A triple mutant, delta dhh1 ssd1-d delta elm1, apparently had very fragile cell walls and could grow only in a medium supplemented with 1 M sorbitol [5].

Associations of ELM1 with chemical compounds


Enzymatic interactions of ELM1

  • In vitro studies with purified recombinant proteins demonstrated that Elm1 directly phosphorylates and activates Gin4, which in turn phosphorylates Shs1 [8].

Regulatory relationships of ELM1


Other interactions of ELM1


  1. Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Sreenivasan, A., Bishop, A.C., Shokat, K.M., Kellogg, D.R. Mol. Cell. Biol. (2003) [Pubmed]
  2. The elm1 kinase functions in a mitotic signaling network in budding yeast. Sreenivasan, A., Kellogg, D. Mol. Cell. Biol. (1999) [Pubmed]
  3. Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex. Sutherland, C.M., Hawley, S.A., McCartney, R.R., Leech, A., Stark, M.J., Schmidt, M.C., Hardie, D.G. Curr. Biol. (2003) [Pubmed]
  4. The control of morphogenesis in Saccharomyces cerevisiae by Elm1 kinase is responsive to RAS/cAMP pathway activity and tryptophan availability. Garrett, J.M. Mol. Microbiol. (1997) [Pubmed]
  5. Analysis of genetic interactions between DHH1, SSD1 and ELM1 indicates their involvement in cellular morphology determination in Saccharomyces cerevisiae. Moriya, H., Isono, K. Yeast (1999) [Pubmed]
  6. ELM1 is required for multidrug resistance in Saccharomyces cerevisiae. Souid, A.K., Gao, C., Wang, L., Milgrom, E., Shen, W.C. Genetics (2006) [Pubmed]
  7. Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28. Edgington, N.P., Blacketer, M.J., Bierwagen, T.A., Myers, A.M. Mol. Cell. Biol. (1999) [Pubmed]
  8. Direct Phosphorylation and Activation of a Nim1-related Kinase Gin4 by Elm1 in Budding Yeast. Asano, S., Park, J.E., Yu, L.R., Zhou, M., Sakchaisri, K., Park, C.J., Kang, Y.H., Thorner, J., Veenstra, T.D., Lee, K.S. J. Biol. Chem. (2006) [Pubmed]
  9. Regulation of cytokinesis by the Elm1 protein kinase in Saccharomyces cerevisiae. Bouquin, N., Barral, Y., Courbeyrette, R., Blondel, M., Snyder, M., Mann, C. J. Cell. Sci. (2000) [Pubmed]
  10. Assembly interdependence among the S. cerevisiae bud neck ring proteins Elm1p, Hsl1p and Cdc12p. Thomas, C.L., Blacketer, M.J., Edgington, N.P., Myers, A.M. Yeast (2003) [Pubmed]
WikiGenes - Universities