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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCT4  -  Cct4p

Saccharomyces cerevisiae S288c

Synonyms: ANC2, CCT-delta, T-complex protein 1 subunit delta, TCP-1-delta, TCP4, ...
 
 
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High impact information on CCT4

  • We previously identified the ANC2 gene in a screen for mutations that enhance the defects caused by yeast actin mutations [1].
  • Here we report that ANC2 is an essential gene that encodes a member of the TCP-1 family [1].
  • Furthermore, overexpression of wild-type Anc2p ameliorates defects in actin organization and cell growth caused by actin overproduction [1].
  • The 14 extragenic noncomplementing mutations represent alleles of at least four different genes, ANC1, ANC2, ANC3 and ANC4 (Actin NonComplementing) [2].

References

  1. A yeast TCP-1-like protein is required for actin function in vivo. Vinh, D.B., Drubin, D.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Screens for extragenic mutations that fail to complement act1 alleles identify genes that are important for actin function in Saccharomyces cerevisiae. Welch, M.D., Vinh, D.B., Okamura, H.H., Drubin, D.G. Genetics (1993) [Pubmed]
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