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Gene Review

CCT4  -  Cct4p

Saccharomyces cerevisiae S288c

Synonyms: ANC2, CCT-delta, T-complex protein 1 subunit delta, TCP-1-delta, TCP4, ...
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High impact information on CCT4

  • We previously identified the ANC2 gene in a screen for mutations that enhance the defects caused by yeast actin mutations [1].
  • Here we report that ANC2 is an essential gene that encodes a member of the TCP-1 family [1].
  • Furthermore, overexpression of wild-type Anc2p ameliorates defects in actin organization and cell growth caused by actin overproduction [1].
  • The 14 extragenic noncomplementing mutations represent alleles of at least four different genes, ANC1, ANC2, ANC3 and ANC4 (Actin NonComplementing) [2].


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