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Gene Review

CCT4  -  chaperonin containing TCP1, subunit 4 (delta)

Homo sapiens

Synonyms: CCT-DELTA, CCT-delta, CCTD, Cctd, SRB, ...
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Disease relevance of CCT4


Psychiatry related information on CCT4

  • All subjects were initially examined and Tanner-staged by a physician (SRB), and instructed in self-assessment using the Tanner photographs; they then performed a self-assessment [6].

High impact information on CCT4

  • A large multisubunit complex containing RNA polymerase II, general transcription factors and SRB regulatory proteins initiates transcription of class II genes in yeast cells [7].
  • A human RNA polymerase II complex associated with SRB and DNA-repair proteins [8].
  • Three groups of mediator polypeptides could be distinguished: the products of five SRB genes, identified as suppressors of carboxy-terminal domain (CTD)-truncation mutants; products of four genes identified as global repressors; and six members of a new protein family, termed Med, thought to be primarily responsible for transcriptional activation [9].
  • Metabolic activities and counts of methanogenic (MB) and sulfate-reducing (SRB) bacteria were measured in feces [10].
  • Three proteins were identified in the cofactor fraction including two previously described proteins, elongation factor 1alpha (EF-1alpha) and the polypyrimidine tract-binding protein (PTB), and a novel protein designated the stimulator of TAR RNA-binding proteins (SRB) [11].

Chemical compound and disease context of CCT4


Biological context of CCT4

  • The cloning was achieved by amplification of a genomic library in the SRB (P2) host strain that allowed the replication of nonstandard DNA structures [17].
  • Cell proliferation was measured using the SRB protein dye [18].
  • However, HCT-8 and HCT-15 cells expressing significant levels of mdr-1 were less sensitive (IC50 2.3 and 3.7 nM, respectively) using a SRB assay [19].
  • Cell metabolic activity was assessed using the MTT assay, cell number using the SRB assay, and cell attachment from hepatocyte total protein content and protein synthesis using [14C]leucine incorporation [20].
  • The functional linkage of acLDL binding to the cloned SRB-like S. mansoni gene using RNA interference (RNAi) suggests a possible role of the tegumental SRB-like protein as a receptor for modified LDL [21].

Anatomical context of CCT4

  • This study reports on the in vitro anticancer properties of BITC against a variety of human and murine tumor cell lines by four independent methods; SRB, MTT, cell counting, and clonogenic assays [22].
  • Their antitumor activities were evaluated in vitro by SRB method for A-549 and BEL-7402 cells, and MTT method for P-388 and HL-60 cells [23].
  • To investigate the antiangiogenic potential of 10-hydroxycamptothecin (HCPT), the proliferation of human microvascular endothelial cells (HMEC) and seven human tumor cell lines were detected by SRB assay, and the endothelial cell migration and tube formation were assessed using two in vitro model systems [24].

Associations of CCT4 with chemical compounds

  • The other controls had high SRB counts and sulfate reduction rates [10].
  • Following 96-h drug exposure in a 5-day sulphohodamine B (SRB) in vitro assay, taxol demonstrated potent cytotoxicity in cell lines which were cisplatin sensitive (577 LM, H32, H12.1; mean IC50s 1.5-3.0 nM) or those with acquired or intrinsic cisplatin resistance (H12DDP, H23.1; mean IC50s 2.5 nM) [25].
  • As a consequence, the sulfide-oxidizing capacities of the biofilms became high enough to completely oxidize all H(2)S produced by SRB to SO(4)(2-) in the second phase, indicating establishment of the complete sulfur cycle in the biofilms [26].
  • By an SRB viability assay, we demonstrated that baicalein reduced the viability in a dose- and time-dependent manner [27].
  • The factors governing competitive interactions between SRB and other anaerobes involved in methanogenesis is discussed in the context of literature data on sulphate wastewater treatment and with particular reference to laboratory and full-scale digestion of citric acid production wastewater [28].

Other interactions of CCT4

  • Thus there was no significant difference noted for the following reagents: OKT4, CCT4, Leu 3a, Leu 2a, OKT8, or CCT8 [29].

Analytical, diagnostic and therapeutic context of CCT4


  1. Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells. Takahashi, N., Li, W.W., Banerjee, D., Scotto, K.W., Bertino, J.R. Clin. Cancer Res. (2001) [Pubmed]
  2. Effects of melatonin on proliferation of cancer cell lines. Papazisis, K.T., Kouretas, D., Geromichalos, G.D., Sivridis, E., Tsekreli, O.K., Dimitriadis, K.A., Kortsaris, A.H. J. Pineal Res. (1998) [Pubmed]
  3. Bcl-x(L) antisense oligonucleotides induce apoptosis and increase sensitivity of pancreatic cancer cells to gemcitabine. Xu, Z., Friess, H., Solioz, M., Aebi, S., Korc, M., Kleeff, J., Büchler, M.W. Int. J. Cancer (2001) [Pubmed]
  4. Indigenous and contaminant microbes in ultradeep mines. Onstott, T.C., Moser, D.P., Pfiffner, S.M., Fredrickson, J.K., Brockman, F.J., Phelps, T.J., White, D.C., Peacock, A., Balkwill, D., Hoover, R., Krumholz, L.R., Borscik, M., Kieft, T.L., Wilson, R. Environ. Microbiol. (2003) [Pubmed]
  5. Escherichia coli host strains SURE and SRB fail to preserve a palindrome cloned in lambda phage: improved alternate host strains. Doherty, J.P., Lindeman, R., Trent, R.J., Graham, M.W., Woodcock, D.M. Gene (1993) [Pubmed]
  6. Validity of self-assessment of sexual maturation in adolescent male patients with cystic fibrosis. Boas, S.R., Falsetti, D., Murphy, T.D., Orenstein, D.M. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. (1995) [Pubmed]
  7. A mammalian SRB protein associated with an RNA polymerase II holoenzyme. Chao, D.M., Gadbois, E.L., Murray, P.J., Anderson, S.F., Sonu, M.S., Parvin, J.D., Young, R.A. Nature (1996) [Pubmed]
  8. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Maldonado, E., Shiekhattar, R., Sheldon, M., Cho, H., Drapkin, R., Rickert, P., Lees, E., Anderson, C.W., Linn, S., Reinberg, D. Nature (1996) [Pubmed]
  9. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Myers, L.C., Gustafsson, C.M., Bushnell, D.A., Lui, M., Erdjument-Bromage, H., Tempst, P., Kornberg, R.D. Genes Dev. (1998) [Pubmed]
  10. Impaired hydrogen metabolism in pneumatosis cystoides intestinalis. Christl, S.U., Gibson, G.R., Murgatroyd, P.R., Scheppach, W., Cummings, J.H. Gastroenterology (1993) [Pubmed]
  11. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. Wu-Baer, F., Lane, W.S., Gaynor, R.B. J. Biol. Chem. (1996) [Pubmed]
  12. Synthesis, characterization, biocide and toxicological activities of di-n-butyl- and diphenyl-tin(IV)-salicyliden-beta-amino alcohol derivatives. Zamudio-Rivera, L.S., George-Tellez, R., López-Mendoza, G., Morales-Pacheco, A., Flores, E., Höpfl, H., Barba, V., Fernández, F.J., Cabirol, N., Beltrán, H.I. Inorganic chemistry. (2005) [Pubmed]
  13. Chemical, biochemical and pharmacological activity of the novel sterically hindered platinum co-ordination complex, cis-[amminedichloro(2-methylpyridine)] platinum(II) (AMD473). Holford, J., Raynaud, F., Murrer, B.A., Grimaldi, K., Hartley, J.A., Abrams, M., Kelland, L.R. Anticancer Drug Des. (1998) [Pubmed]
  14. Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. Houghton, P.J., Photiou, A., Uddin, S., Shah, P., Browning, M., Jackson, S.J., Retsas, S. Planta Med. (1994) [Pubmed]
  15. Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii. López-Lázaro, M., Palma De La Peña, N., Pastor, N., Martín-Cordero, C., Navarro, E., Cortés, F., Ayuso, M.J., Toro, M.V. Planta Med. (2003) [Pubmed]
  16. Cytotoxic activity of indole alkaloids from Alstonia macrophylla. Keawpradub, N., Eno-Amooquaye, E., Burke, P.J., Houghton, P.J. Planta Med. (1999) [Pubmed]
  17. Characterization of the promoter-regulatory region and structural organization of E1 alpha gene (BCKDHA) of human branched-chain alpha-keto acid dehydrogenase complex. Chuang, J.L., Cox, R.P., Chuang, D.T. J. Biol. Chem. (1993) [Pubmed]
  18. Doxycycline induces caspase-dependent apoptosis in human pancreatic cancer cells. Mouratidis, P.X., Colston, K.W., Dalgleish, A.G. Int. J. Cancer (2007) [Pubmed]
  19. Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136. Guichard, S.M., Macpherson, J.S., Thurston, D.E., Jodrell, D.I. Eur. J. Cancer (2005) [Pubmed]
  20. The effects of immunosuppressive agents on the function of human hepatocytes in vitro. Serrano, T., Mitry, R.R., Terry, C., Lehec, S.C., Dhawan, A., Hughes, R.D. Cell transplantation (2006) [Pubmed]
  21. Potential role of a CD36-like class B scavenger receptor in the binding of modified low-density lipoprotein (acLDL) to the tegumental surface of Schistosoma mansoni sporocysts. Dinguirard, N., Yoshino, T.P. Mol. Biochem. Parasitol. (2006) [Pubmed]
  22. In vitro and in vivo antitumor activity of benzyl isothiocyanate: a natural product from Tropaeolum majus. Pintão, A.M., Pais, M.S., Coley, H., Kelland, L.R., Judson, I.R. Planta Med. (1995) [Pubmed]
  23. Synthesis, structure analysis, and antitumor activity of 3,6-disubstituted-1,4-dihydro-1,2,4,5-tetrazine derivatives. Rao, G.W., Hu, W.X. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  24. Antiangiogenic potential of 10-hydroxycamptothecin. Xiao, D., Tan, W., Li, M., Ding, J. Life Sci. (2001) [Pubmed]
  25. Pre-clinical activity of taxol in non-seminomatous germ cell tumor cell lines and nude mouse xenografts. Dunn, T.A., Grünwald, V., Bokemeyer, C., Casper, J. Investigational new drugs. (1997) [Pubmed]
  26. Succession of internal sulfur cycles and sulfur-oxidizing bacterial communities in microaerophilic wastewater biofilms. Okabe, S., Ito, T., Sugita, K., Satoh, H. Appl. Environ. Microbiol. (2005) [Pubmed]
  27. Effect of baicalein on apoptosis of the human Hep G2 cell line was induced by mitochondrial dysfunction. Chang, W.H., Chen, C.H., Gau, R.J., Lin, C.C., Tsai, C.L., Tsai, K., Lu, F.J. Planta Med. (2002) [Pubmed]
  28. Anaerobic treatment of sulphate-containing waste streams. Colleran, E., Finnegan, S., Lens, P. Antonie Van Leeuwenhoek (1995) [Pubmed]
  29. Normal human blood density gradient lymphocyte subset analysis: I. An interlaboratory flow cytometric comparison of 85 normal adults. Marti, G.E., Magruder, L., Patrick, K., Vail, M., Schuette, W., Keller, R., Muirhead, K., Horan, P., Gralnick, H.R. Am. J. Hematol. (1985) [Pubmed]
  30. 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Janzowski, C., Glaab, V., Samimi, E., Schlatter, J., Eisenbrand, G. Food Chem. Toxicol. (2000) [Pubmed]
  31. Advances in biotreatment of acid mine drainage and biorecovery of metals: 1. Metal precipitation for recovery and recycle. Tabak, H.H., Scharp, R., Burckle, J., Kawahara, F.K., Govind, R. Biodegradation (2003) [Pubmed]
  32. Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. Li, W.X., Cui, C.B., Cai, B., Wang, H.Y., Yao, X.S. Journal of Asian natural products research. (2005) [Pubmed]
  33. Pro-apoptotic effect of a nitric oxide-donating NSAID, NCX 4040, on bladder carcinoma cells. Fabbri, F., Brigliadori, G., Ulivi, P., Tesei, A., Vannini, I., Rosetti, M., Bravaccini, S., Amadori, D., Bolla, M., Zoli, W. Apoptosis (2005) [Pubmed]
  34. Wild type p53 increased chemosensitivity of drug-resistant human hepatocellular carcinoma Bel7402/5-FU cells. Li, Y.X., Lin, Z.B., Tan, H.R. Acta Pharmacol. Sin. (2004) [Pubmed]
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