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Gene Review

COQ4  -  Coq4p

Saccharomyces cerevisiae S288c

Synonyms: Coenzyme Q biosynthesis protein 4, Ubiquinone biosynthesis protein COQ4, mitochondrial, YD8142.01, YDR204W
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High impact information on COQ4

  • Coq7p co-migrates with the Coq3 and Coq4 polypeptides as a high molecular mass complex [1].
  • These studies show that at least two functions can be attributed to Coq5p; first, it is required to catalyze the C-methyltransferase step in Q biosynthesis and second, it is involved in stabilizing the Coq3 and Coq4 polypeptides required for Q biosynthesis [2].
  • Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis [3].
  • Steady-state levels of COQ4 mRNA were increased during growth on glycerol-containing medium, in accordance with a function in Q biosynthesis [3].
  • Yeast coq4 mutant strains harboring the COQ4 gene on either single- or multicopy plasmids acquired the ability to grow on media containing a nonfermentable carbon source, synthesize Q(6), and respire [3].

Anatomical context of COQ4


  1. Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis. Tran, U.C., Marbois, B., Gin, P., Gulmezian, M., Jonassen, T., Clarke, C.F. J. Biol. Chem. (2006) [Pubmed]
  2. Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis. Baba, S.W., Belogrudov, G.I., Lee, J.C., Lee, P.T., Strahan, J., Shepherd, J.N., Clarke, C.F. J. Biol. Chem. (2004) [Pubmed]
  3. Yeast COQ4 encodes a mitochondrial protein required for coenzyme Q synthesis. Belogrudov, G.I., Lee, P.T., Jonassen, T., Hsu, A.Y., Gin, P., Clarke, C.F. Arch. Biochem. Biophys. (2001) [Pubmed]
  4. Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. Marbois, B., Gin, P., Faull, K.F., Poon, W.W., Lee, P.T., Strahan, J., Shepherd, J.N., Clarke, C.F. J. Biol. Chem. (2005) [Pubmed]
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