Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

GTB1 - Gtb1p

Saccharomyces cerevisiae S288c

Synonyms: Alpha-glucosidase 2 subunit beta, Alpha-glucosidase II subunit beta, Glucosidase 2 subunit beta, Glucosidase II subunit beta, YDR221W

Wilkinson, B.M. et al., Horio, T. et al.

Horio, Kimura, Basaki, Tanaka, Noguchi, Akashi, Tanaka,

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High impact information on GTB1

Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum [1].
Our data demonstrate that Gtb1p is required for normal glycoprotein biogenesis and reveal that the final two glucose-trimming steps in N-glycan processing are mechanistically distinct [1].
The Gtb1 protein was shown to be a soluble glycoprotein (96-102 kDa) localized to the endoplasmic reticulum lumen where it was present in a complex together with the yeast alpha-subunit homologue Gls2p [1].
The Accession No. for the nucleotide sequence of the Sz. japonicus gtb1(+) gene is AF159163 [2].

Other interactions of GTB1

Thus, although Gls2p is sufficient for cleavage of the penultimate glucose residue, Gtb1p is essential for cleavage of the final glucose [1].

References

Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum. Wilkinson, B.M., Purswani, J., Stirling, C.J. J. Biol. Chem. (2006) [Pubmed]
Molecular and structural characterization of the spindle pole bodies in the fission yeast Schizosaccharomyces japonicus var japonicus. Horio, T., Kimura, N., Basaki, A., Tanaka, Y., Noguchi, T., Akashi, T., Tanaka, K. Yeast (2002) [Pubmed]

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