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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TIM11  -  F1F0 ATP synthase subunit e

Saccharomyces cerevisiae S288c

Synonyms: ATP synthase subunit e, mitochondrial, ATP21, ATPase subunit e, Translocase of the inner membrane protein 11, YDR322BC, ...
 
 
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High impact information on TIM11

  • Su e/Tim11 appears to play a central role in this dimerization process [1].
  • Import of Mcr1p into the intermembrane space requires an electrochemical potential across the inner membrane, as well as ATP in the matrix, and is strongly impaired in mitochondria lacking Tom7p or Tim11p, two components of the translocation machineries in the outer and inner mitochondrial membranes, respectively [2].
  • We show that Mgm1p serves as an upstream regulator of Tim11p protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae [3].
  • Another is Tim11p, which is required for oligomeric assembly of F1Fo-ATP synthase, which generates ATP through oxidative phosphorylation [3].

References

  1. Yeast mitochondrial F1F0-ATP synthase exists as a dimer: identification of three dimer-specific subunits. Arnold, I., Pfeiffer, K., Neupert, W., Stuart, R.A., Schägger, H. EMBO J. (1998) [Pubmed]
  2. Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria. Haucke, V., Ocana, C.S., Hönlinger, A., Tokatlidis, K., Pfanner, N., Schatz, G. Mol. Cell. Biol. (1997) [Pubmed]
  3. A novel role of Mgm1p, a dynamin-related GTPase, in ATP synthase assembly and cristae formation/maintenance. Amutha, B., Gordon, D.M., Gu, Y., Pain, D. Biochem. J. (2004) [Pubmed]
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