Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

TOM7 - Tom7p

Saccharomyces cerevisiae S288c

Synonyms: MOM7, Mitochondrial import receptor subunit TOM7, N2378, Translocase of outer membrane 7 kDa subunit, YNL070W, ...

Allen, R. et al., Haucke, V. et al., Dembowski, M. et al., Dietmeier, K. et al., Jänsch, L. et al., et al.

Haucke, Ocana, Hönlinger, Tokatlidis, Pfanner, Schatz,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TOM7

Tom40 is an essential constituent of the GIP, whereas Tom6 and Tom7 modulate the assembly and dissociation of the Tom machinery [1].
Maturation to the 400 kDa complex occurs by association of Tom7 and Tom22 [2].
Import of Mcr1p into the intermembrane space requires an electrochemical potential across the inner membrane, as well as ATP in the matrix, and is strongly impaired in mitochondria lacking Tom7p or Tim11p, two components of the translocation machineries in the outer and inner mitochondrial membranes, respectively [3].
Sequence analysis of cDNAs encoding the 7-kDa protein revealed significant sequence homology of this protein to TOM7 from yeast [4].
A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase [5].

Biological context of TOM7

The insertion pathway of these proteins shares a common binding site with the general import pathway as the assembly of both Tom6 and Tom7 was competed by a matrix-destined precursor protein [6].

References

Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Dietmeier, K., Hönlinger, A., Bömer, U., Dekker, P.J., Eckerskorn, C., Lottspeich, F., Kübrich, M., Pfanner, N. Nature (1997) [Pubmed]
Multistep assembly of the protein import channel of the mitochondrial outer membrane. Model, K., Meisinger, C., Prinz, T., Wiedemann, N., Truscott, K.N., Pfanner, N., Ryan, M.T. Nat. Struct. Biol. (2001) [Pubmed]
Analysis of the sorting signals directing NADH-cytochrome b5 reductase to two locations within yeast mitochondria. Haucke, V., Ocana, C.S., Hönlinger, A., Tokatlidis, K., Pfanner, N., Schatz, G. Mol. Cell. Biol. (1997) [Pubmed]
Unique composition of the preprotein translocase of the outer mitochondrial membrane from plants. Jänsch, L., Kruft, V., Schmitz, U.K., Braun, H.P. J. Biol. Chem. (1998) [Pubmed]
A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase. Allen, R., Egan, B., Gabriel, K., Beilharz, T., Lithgow, T. FEBS Lett. (2002) [Pubmed]
Assembly of Tom6 and Tom7 into the TOM core complex of Neurospora crassa. Dembowski, M., Kunkele, K.P., Nargang, F.E., Neupert, W., Rapaport, D. J. Biol. Chem. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.