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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SXM1  -  Sxm1p

Saccharomyces cerevisiae S288c

Synonyms: Importin beta SMX1, KAP108, Suppressor of mRNA export mutant protein 1, YDR395W, karyopherin-108
 
 
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High impact information on SXM1

  • Further, we demonstrate that Lhp1p is specifically imported by Sxm1p [1].
  • From yeast cytosol, we isolated Sxm1p in complex with several potential import substrates [1].
  • In addition, through its association with ribosomal proteins, Sxm1p may have a role in coordinating ribosome biogenesis with tRNA processing [1].
  • Thus, a major role of Pse1p, Kap123p, and Sxm1p may be nuclear export rather than import, suggesting a symmetrical relationship between these processes [2].
  • In order to understand how nuclear transporters traverse the NPC, we constructed functional protein fusions between several members of the yeast importin family, including Pse1p, Sxm1p, Xpo1p, and Kap95p, and the green fluorescent protein (GFP) [3].
 

Other interactions of SXM1

  • Import of Pab1 is mediated by the import receptor Kap108/Sxm1 through a nuclear localization signal in its fourth RNA-binding domain [4].
  • AlcR can be imported into nuclei via multiple transport pathways mediated by a distinct set of karyopherins composed of Kap104p, Sxm1p, and Nmd5p transport receptors [5].

References

  1. A nuclear import pathway for a protein involved in tRNA maturation. Rosenblum, J.S., Pemberton, L.F., Blobel, G. J. Cell Biol. (1997) [Pubmed]
  2. Importin/karyopherin protein family members required for mRNA export from the nucleus. Seedorf, M., Silver, P.A. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  3. Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase. Seedorf, M., Damelin, M., Kahana, J., Taura, T., Silver, P.A. Mol. Cell. Biol. (1999) [Pubmed]
  4. Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. Brune, C., Munchel, S.E., Fischer, N., Podtelejnikov, A.V., Weis, K. RNA (2005) [Pubmed]
  5. Nuclear import of zinc binuclear cluster proteins proceeds through multiple, overlapping transport pathways. Nikolaev, I., Cochet, M.F., Felenbok, B. Eukaryotic Cell (2003) [Pubmed]
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