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Gene Review

TFB3  -  TFIIH/NER complex subunit TFB3

Saccharomyces cerevisiae S288c

Synonyms: RIG2, RNA polymerase II transcription factor B 38 kDa subunit, RNA polymerase II transcription factor B p38 subunit, RNA polymerase II transcription factor B subunit 3, YDR460W
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High impact information on TFB3


Other interactions of TFB3

  • Moreover, cells containing kin28(T162A) and a conditional allele of TFB3 (the ortholog of the mammalian MAT1 protein, an assembly factor for MO15 and cyclin H) are severely compromised and display a significant further reduction in Kin28p activity [6].


  1. Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Keogh, M.C., Cho, E.J., Podolny, V., Buratowski, S. Mol. Cell. Biol. (2002) [Pubmed]
  2. Mutations in the RING domain of TFB3, a subunit of yeast transcription factor IIH, reveal a role in cell cycle progression. Jona, G., Livi, L.L., Gileadi, O. J. Biol. Chem. (2002) [Pubmed]
  3. Subunit interactions in yeast transcription/repair factor TFIIH. Requirement for Tfb3 subunit in nucleotide excision repair. Feaver, W.J., Huang, W., Gileadi, O., Myers, L., Gustafsson, C.M., Kornberg, R.D., Friedberg, E.C. J. Biol. Chem. (2000) [Pubmed]
  4. Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits. Feaver, W.J., Henry, N.L., Wang, Z., Wu, X., Svejstrup, J.Q., Bushnell, D.A., Friedberg, E.C., Kornberg, R.D. J. Biol. Chem. (1997) [Pubmed]
  5. Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci. Walsh, D.W., Wolfe, K.H., Butler, G. Yeast (2002) [Pubmed]
  6. Activating phosphorylation of the Kin28p subunit of yeast TFIIH by Cak1p. Kimmelman, J., Kaldis, P., Hengartner, C.J., Laff, G.M., Koh, S.S., Young, R.A., Solomon, M.J. Mol. Cell. Biol. (1999) [Pubmed]
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