Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

HLR1 - Hlr1p

Saccharomyces cerevisiae S288c

Synonyms: D9719.31, LRE1 homolog, Protein HLR1, YDR528W

Versele, M. et al., Alonso-Monge, R. et al.

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High impact information on HLR1

Deletion and overexpression of HLR1 causes similar but less pronounced effects compared with LRE1 [1].
Instead, the ste11ssk2ssk2 strain displayed a hyperosmosensitive phenotype at 37 degrees C. This phenotype is suppressed by overexpression of LRE1, HLR1 and WSC3, all genes known to influence cell wall composition [2].
LRE1 and HLR1 were also shown to suppress the cell wall phenotypes associated with the HOG pathway mutants [2].

Biological context of HLR1

The yeast genome contains a homologue of LRE1, YDR528w, which we have called HLR1 (for homologue of Lre1) [1].

References

Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae. Versele, M., Thevelein, J.M. Mol. Microbiol. (2001) [Pubmed]
Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Alonso-Monge, R., Real, E., Wojda, I., Bebelman, J.P., Mager, W.H., Siderius, M. Mol. Microbiol. (2001) [Pubmed]

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