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Gene Review

LRE1  -  Lre1p

Saccharomyces cerevisiae S288c

Synonyms: Laminarase-resistance protein LRE1, YCL051W, YCL51W
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High impact information on LRE1

  • Deletion and overexpression of HLR1 causes similar but less pronounced effects compared with LRE1 [1].
  • In addition, we show that increased trehalose accumulation and increased heat resistance caused by overexpression of LRE1 are also the result of inhibition of Cbk1, revealing a novel control pathway for certain targets affected by PKA [1].
  • Deletion of LRE1 results in the opposite phenotypes [1].
  • We have isolated the LRE1 gene as a multicopy suppressor of glucose-induced loss of heat resistance [1].
  • Lre1 affects chitinase expression, trehalose accumulation and heat resistance through inhibition of the Cbk1 protein kinase in Saccharomyces cerevisiae [1].

Biological context of LRE1


Anatomical context of LRE1

  • Unexpectedly, cells carrying LRE1 at multiple copy show no alteration in cell wall glucans or glucan synthase activity [2].

Associations of LRE1 with chemical compounds

  • Overexpression of LRE1 in a wild-type strain causes the same phenotype as observed in strains with reduced activity of the cAMP-PKA pathway: higher heat resistance and enhanced trehalose levels [1].

Other interactions of LRE1


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