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Gene Review:

WSC3 - Wsc3p

Saccharomyces cerevisiae S288c

Synonyms: Cell wall integrity and stress response component 3, HRE556, YOL105C

Alonso-Monge, R. et al., Zu, T. et al., Verna, J. et al.

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Disease relevance of WSC3

The genes WSC1, WSC2 and WSC3 encode putative receptors that maintain cell wall integrity under conditions of heat stress [1].

High impact information on WSC3

Instead, the ste11ssk2ssk2 strain displayed a hyperosmosensitive phenotype at 37 degrees C. This phenotype is suppressed by overexpression of LRE1, HLR1 and WSC3, all genes known to influence cell wall composition [2].
Deletion of WSC1 causes a cell lysis defect that is exacerbated by deleting WSC2 or WSC3 [3].

References

Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Zu, T., Verna, J., Ballester, R. Mol. Genet. Genomics (2001) [Pubmed]
Hyperosmotic stress response and regulation of cell wall integrity in Saccharomyces cerevisiae share common functional aspects. Alonso-Monge, R., Real, E., Wojda, I., Bebelman, J.P., Mager, W.H., Siderius, M. Mol. Microbiol. (2001) [Pubmed]
A novel role for the mating type (MAT) locus in the maintenance of cell wall integrity in Saccharomyces cerevisiae. Verna, J., Ballester, R. Mol. Gen. Genet. (1999) [Pubmed]

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