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Gene Review:

AST1 - Ast1p

Saccharomyces cerevisiae S288c

Synonyms: Protein AST1, YBL06.04, YBL0617, YBL069W

Chang, A. et al., Bagnat, M. et al.

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High impact information on AST1

A novel gene, AST1, identified by this selection, suppresses several pma1 alleles defective for targeting [1].
Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole [1].
Ast1 is a cytoplasmic protein that associates with membranes, and is localized to multiple compartments, including the plasma membrane [1].

Associations of AST1 with chemical compounds

Ast1p, which is a peripheral membrane protein, was found to directly interact with Pma1p inducing its clustering into a SDS/Triton X100-resistant oligomer [2].

References

Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. Chang, A., Fink, G.R. J. Cell Biol. (1995) [Pubmed]
Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. Bagnat, M., Chang, A., Simons, K. Mol. Biol. Cell (2001) [Pubmed]

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