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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HHT1  -  histone H3

Saccharomyces cerevisiae S288c

Synonyms: BUR5, SIN2
 
 
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High impact information on HHT1

  • Here we show that SIN2 is identical to HHT1, one of the two genes coding for histone H3, and that mutations in either can result in a Sin- phenotype [1].
  • An initial screen of meiotically expressed yeast genes revealed several genes associated with chromosome metabolism (e.g., RAD51 and HHT1 as well as others) [2].
  • Finally, BUR5 is identical to HHT1, encoding histone H3, further implicating chromatin structure as important for expression of SUC2 [3].
  • DNA sequencing has also shown that the K. lactis TRP1 sequence is flanked by genes encoding inorganic pyrophosphatase and histone H3, which we have designated IPP and HHT1 respectively [4].

References

  1. Amino acid substitutions in the structured domains of histones H3 and H4 partially relieve the requirement of the yeast SWI/SNF complex for transcription. Kruger, W., Peterson, C.L., Sil, A., Coburn, C., Arents, G., Moudrianakis, E.N., Herskowitz, I. Genes Dev. (1995) [Pubmed]
  2. Yeast and human genes that affect the Escherichia coli SOS response. Perkins, E.L., Sterling, J.F., Hashem, V.I., Resnick, M.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo. Prelich, G., Winston, F. Genetics (1993) [Pubmed]
  4. Cloning and analysis of the Kluyveromyces lactis TRP1 gene: a chromosomal locus flanked by genes encoding inorganic pyrophosphatase and histone H3. Stark, M.J., Milner, J.S. Yeast (1989) [Pubmed]
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