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Gene Review

IPP1  -  inorganic diphosphatase IPP1

Saccharomyces cerevisiae S288c

Synonyms: Inorganic pyrophosphatase, PPA, PPA1, PPase, Pyrophosphate phospho-hydrolase, ...
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Disease relevance of IPP1


High impact information on IPP1


Chemical compound and disease context of IPP1


Biological context of IPP1


Anatomical context of IPP1


Associations of IPP1 with chemical compounds


Other interactions of IPP1


Analytical, diagnostic and therapeutic context of IPP1


  1. Fluoride effects along the reaction pathway of pyrophosphatase: evidence for a second enzyme.pyrophosphate intermediate. Baykov, A.A., Fabrichniy, I.P., Pohjanjoki, P., Zyryanov, A.B., Lahti, R. Biochemistry (2000) [Pubmed]
  2. Purification and properties of inorganic pyrophosphatase of rat liver and hepatoma 3924A. Yoshida, C., Shah, H., Weinhouse, S. Cancer Res. (1982) [Pubmed]
  3. Comparative kinetic studies on the two interconvertible forms of Streptococcus faecalis inorganic pyrophosphatase. Lahti, R., Lönnberg, H. Biochem. J. (1985) [Pubmed]
  4. Characterization of a soluble inorganic pyrophosphatase from Microcystis aeruginosa and preparation of its antibody. Kang, C.B., Ho, K.K. Arch. Biochem. Biophys. (1991) [Pubmed]
  5. Nucleotide phosphotransferase, nucleotide kinase and inorganic pyrophosphatase activities of killer virions of yeast. Georgopoulos, D.E., Leibowitz, M.J. Yeast (1987) [Pubmed]
  6. Evolutionary conservation of the active site of soluble inorganic pyrophosphatase. Cooperman, B.S., Baykov, A.A., Lahti, R. Trends Biochem. Sci. (1992) [Pubmed]
  7. T4 polynucleotide kinase; cloning of the gene (pseT) and amplification of its product. Midgley, C.A., Murray, N.E. EMBO J. (1985) [Pubmed]
  8. Gene order evolution and paleopolyploidy in hemiascomycete yeasts. Wong, S., Butler, G., Wolfe, K.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Functional complementation of yeast cytosolic pyrophosphatase by bacterial and plant H+-translocating pyrophosphatases. Perez-Castineira, J.R., Lopez-Marques, R.L., Villalba, J.M., Losada, M., Serrano, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  10. Evaluation of the partitioning of bound inorganic phosphate during medium and intermediate phosphate in equilibrium water oxygen exchange reactions of yeast inorganic pyrophosphatase. Hackney, D.D., Boyer, P.D. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  11. Tightly bound pyrophosphate in Escherichia coli inorganic pyrophosphatase. Shestakov, A.A., Baykov, A.A., Avaeva, S.M. FEBS Lett. (1990) [Pubmed]
  12. Yeast PPA2 gene encodes a mitochondrial inorganic pyrophosphatase that is essential for mitochondrial function. Lundin, M., Baltscheffsky, H., Ronne, H. J. Biol. Chem. (1991) [Pubmed]
  13. Covalent structural analysis of yeast inorganic pyrophosphatase. Cohen, S.A., Sterner, R., Keim, P.S., Heinrikson, R.L. J. Biol. Chem. (1978) [Pubmed]
  14. Cloning, molecular characterization and chromosome localization of the inorganic pyrophosphatase (PPA) gene from S. cerevisiae. Kolakowski, L.F., Schloesser, M., Cooperman, B.S. Nucleic Acids Res. (1988) [Pubmed]
  15. Nucleotide sequence of S. pombe inorganic pyrophosphatase. Kawasaki, I., Adachi, N., Ikeda, H. Nucleic Acids Res. (1990) [Pubmed]
  16. The R78K and D117E active-site variants of Saccharomyces cerevisiae soluble inorganic pyrophosphatase: structural studies and mechanistic implications. Tuominen, V., Heikinheimo, P., Kajander, T., Torkkel, T., Hyytiä, T., Käpylä, J., Lahti, R., Cooperman, B.S., Goldman, A. J. Mol. Biol. (1998) [Pubmed]
  17. Inorganic pyrophosphate gives a membrane potential in yeast mitochondria, as measured with the permeant cation tetraphenylphosphonium. Pereira-da-Silva, L., Sherman, M., Lundin, M., Baltscheffsky, H. Arch. Biochem. Biophys. (1993) [Pubmed]
  18. Properties of inorganic pyrophosphatase of pig scapula cartilage. Felix, R., Fleisch, H. Biochem. J. (1975) [Pubmed]
  19. H(+)-translocating inorganic pyrophosphatase of plant vacuoles. Inhibition by Ca2+, stabilization by Mg2+ and immunological comparison with other inorganic pyrophosphatases. Maeshima, M. Eur. J. Biochem. (1991) [Pubmed]
  20. Synthesis of pyrophosphate by chromatophores of Rhodospirillum rubrum in the light and by soluble yeast inorganic pyrophosphatase in water-organic solvent mixtures. Behrens, M.I., De Meis, L. Eur. J. Biochem. (1985) [Pubmed]
  21. Thermodynamics, kinetics, and mechanism in yeast inorganic pyrophosphatase catalysis of inorganic pyrophosphate: inorganic phosphate equilibration. Springs, B., Welsh, K.M., Cooperman, B.S. Biochemistry (1981) [Pubmed]
  22. Evidence that catalysis by yeast inorganic pyrophosphatase proceeds by direct phosphoryl transfer to water and not via a phosphoryl enzyme intermediate. Gonzalez, M.A., Webb, M.R., Welsh, K.M., Cooperman, B.S. Biochemistry (1984) [Pubmed]
  23. Investigation of the regiospecificity and stereospecificity of proton transfer in the yeast inorganic pyrophosphatase catalyzed reaction. Lin, I., Knight, W.B., Hsueh, A., Dunaway-Mariano, D. Biochemistry (1986) [Pubmed]
  24. Identification of an arginine important for enzymatic activity within the covalent structure of yeast inorganic pyrophosphatase. Bond, M.W., Chiu, N.Y., Cooperman, B.S. Biochemistry (1980) [Pubmed]
  25. Enzyme-catalyzed organic synthesis of sucrose and trehalose with in situ regeneration of UDP-glucose. Haynie, S.L., Whitesides, G.M. Appl. Biochem. Biotechnol. (1990) [Pubmed]
  26. Molecular cloning and functional expression of cDNA encoding a mammalian inorganic pyrophosphatase. Yang, Z., Wensel, T.G. J. Biol. Chem. (1992) [Pubmed]
  27. Expression of Saccharomyces cerevisiae inorganic pyrophosphatase in Escherichia coli. Kurilova, S.A., Vorobjeva, N.N., Nazarova, T.I., Avaeva, S.M. FEBS Lett. (1993) [Pubmed]
  28. The role of histidine-118 of inorganic pyrophosphatase from thermophilic bacterium PS-3. Hirano, N., Ichiba, T., Hachimori, A. Biochem. J. (1991) [Pubmed]
  29. Inorganic pyrophosphate generation from adenosine triphosphate by cell-free human synovial fluid. Park, W., Masuda, I., Cardenal-Escarcena, A., Palmer, D.L., McCarty, D.J. J. Rheumatol. (1996) [Pubmed]
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