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Gene Review

FIG1  -  Fig1p

Saccharomyces cerevisiae S288c

Synonyms: Factor-induced gene 1 protein, YBR040W, YBR0410
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High impact information on FIG1

  • Fig1p and Fig2p are likely to act at the cell surface as Fig1:: beta-gal and Fig2::beta-gal fusion proteins localize to the periphery of mating cells [1].
  • We show that deletion of FIG 1, which controls pheromone-induced Ca(2+) influx, yields similar cell fusion defects [2].
  • The Plasma Membrane Proteins Prm1 and Fig1 Ascertain Fidelity of Membrane Fusion during Yeast Mating [2].
  • Thus, our results suggest that Prm1 and Fig1 have a role in enhancing membrane fusion and maintaining its fidelity [2].
  • Rapid cell death required Fig1, a transmembrane protein homologous to PMP-22/EMP/MP20/Claudin proteins, but did not require its Ca2+ influx activity [3].

Biological context of FIG1


Anatomical context of FIG1

  • Interestingly a polytopic plasma membrane protein, Fig1p, was required for LACS activity but not required for activation of Mpk1p mitogen-activated protein kinase [4].

Other interactions of FIG1

  • Several cochaperone mutants tested had reduced FIG1 induction or HHF1 repression, although to differing extents [5].


  1. Pheromone-regulated genes required for yeast mating differentiation. Erdman, S., Lin, L., Malczynski, M., Snyder, M. J. Cell Biol. (1998) [Pubmed]
  2. The Plasma Membrane Proteins Prm1 and Fig1 Ascertain Fidelity of Membrane Fusion during Yeast Mating. Aguilar, P.S., Engel, A., Walter, P. Mol. Biol. Cell (2007) [Pubmed]
  3. Multiple signaling pathways regulate yeast cell death during the response to mating pheromones. Zhang, N.N., Dudgeon, D.D., Paliwal, S., Levchenko, A., Grote, E., Cunningham, K.W. Mol. Biol. Cell (2006) [Pubmed]
  4. Fig1p facilitates Ca2+ influx and cell fusion during mating of Saccharomyces cerevisiae. Muller, E.M., Mackin, N.A., Erdman, S.E., Cunningham, K.W. J. Biol. Chem. (2003) [Pubmed]
  5. Sti1 and Cdc37 can stabilize Hsp90 in chaperone complexes with a protein kinase. Lee, P., Shabbir, A., Cardozo, C., Caplan, A.J. Mol. Biol. Cell (2004) [Pubmed]
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