High impact information on GIP1

• Here we show that GIP1 and the protein phosphatase 1 encoded by GLC7 play essential roles in spore development [1].
• A Gip1p-Glc7p phosphatase complex regulates septin organization and spore wall formation [1].
• Similar phenotypes were observed in a glc7-136 mutant, which expresses a Glc7p defective in interacting with Gip1p [1].
• Molecular and genetic analyses indicate that GIP1 is expressed specifically during meiosis, affects transcription of late meiotic genes, and is essential for sporulation [2].
• In this study, we focused on nine putative open reading frames (ORFs) closely linked to PKS12 and GIP1, which are required for aurofusarin biosynthesis in G. zeae [3].

Biological context of GIP1

• The Glc7p/Gip1p holoenzyme may participate in completion of meiotic divisions or spore packaging because meiotic dyads predominate when some glc7 diploids sporulate [4].

Anatomical context of GIP1

• Localization studies revealed that Gip1p and Glc7p colocalize with the septins in structures underlying the growing prospore membranes [1].

References