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Gene Review:

UBP14 - Ubp14p

Saccharomyces cerevisiae S288c

Synonyms: Deubiquitinating enzyme 14, GID6, Glucose-induced degradation protein 6, Ubiquitin carboxyl-terminal hydrolase 14, Ubiquitin thioesterase 14, ...

Doelling, J.H. et al., Regelmann, J. et al., Amerik AYu, n.u.l.l. et al., Lindsey, D.F. et al.

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High impact information on UBP14

Inhibition of degradation is also seen when an active site mutant of Ubp14 is overproduced in vivo [1].
The influence of Ubp14p, a deubiquitinating enzyme, on proteasome-dependent catabolite degradation was further uncovered [2].
UbpA has sequence similarity with yeast Ubp14, which disassembles free ubiquitin chains [3].
The ubiquitin-specific protease UBP14 is essential for early embryo development in Arabidopsis thaliana [4].
Its amino acid sequence is most similar to yeast UBP14 and its orthologues, human IsoT1-3 and Dictyostelium UbpA, and it can functionally replace yeast UBP14 in a ubp14Delta mutant [4].

References

In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome. Amerik AYu, n.u.l.l., Swaminathan, S., Krantz, B.A., Wilkinson, K.D., Hochstrasser, M. EMBO J. (1997) [Pubmed]
Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways. Regelmann, J., Schüle, T., Josupeit, F.S., Horak, J., Rose, M., Entian, K.D., Thumm, M., Wolf, D.H. Mol. Biol. Cell (2003) [Pubmed]
A deubiquitinating enzyme that disassembles free polyubiquitin chains is required for development but not growth in Dictyostelium. Lindsey, D.F., Amerik, A., Deery, W.J., Bishop, J.D., Hochstrasser, M., Gomer, R.H. J. Biol. Chem. (1998) [Pubmed]
The ubiquitin-specific protease UBP14 is essential for early embryo development in Arabidopsis thaliana. Doelling, J.H., Yan, N., Kurepa, J., Walker, J., Vierstra, R.D. Plant J. (2001) [Pubmed]

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AGOS_AGR023C	Ashbya gossypii ATCC 10895
KLLA0F18700g	Kluyveromyces lactis NRRL Y-1140
MGG_08270	Magnaporthe oryzae 70-15
NCU05777	Neurospora crassa OR74A
ubp14	Schizosaccharomyces pombe 972h-

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