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Gene Review:

TSC3 - Tsc3p

Saccharomyces cerevisiae S288c

Synonyms: Serine palmitoyltransferase-regulating protein TSC3, Temperature-sensitive CSG2-mutant suppressor protein 3, YBR058C-A

Monaghan, E. et al., Gable, K. et al.

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High impact information on TSC3

Lcb1p and Lcb2p remain tightly associated with each other and localize to the membrane in cells lacking Tsc3p [1].
Here, we report the characterization of a third gene, TSC3, required for optimal 3-ketosphinganine synthesis in Saccharomyces cerevisiae [1].
S. cerevisiae cells lacking the TSC3 gene have a temperature-sensitive lethal phenotype that is reversed by supplying 3-ketosphinganine, dihydrosphingosine, or phytosphingosine in the growth medium [1].
Tsc3p is essential for cell viability only at elevated temperatures, although serine palmitoyltransferase activity is reduced in the tsc3 delta mutant, even at permissive growth temperatures [2].

Associations of TSC3 with chemical compounds

Tsc3p is apparently not required for any essential process besides stimulation of serine palmitoyltransferase at 37 degrees C, since providing sphingoid bases to the growth medium reverses the temperature-sensitive growth phenotype of the tsc3 delta mutant [2].

References

Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. Gable, K., Slife, H., Bacikova, D., Monaghan, E., Dunn, T.M. J. Biol. Chem. (2000) [Pubmed]
Mutations in the Lcb2p subunit of serine palmitoyltransferase eliminate the requirement for the TSC3 gene in Saccharomyces cerevisiae. Monaghan, E., Gable, K., Dunn, T. Yeast (2002) [Pubmed]

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