Gene Review:
LCB2 - serine C-palmitoyltransferase LCB2
Saccharomyces cerevisiae S288c
Synonyms:
D4246, Long chain base biosynthesis protein 2, SCS1, SPT 2, Serine palmitoyltransferase 2, ...
- Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. Gable, K., Han, G., Monaghan, E., Bacikova, D., Natarajan, M., Williams, R., Dunn, T.M. J. Biol. Chem. (2002)
- Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. van Slegtenhorst, M., Mustafa, A., Henske, E.P. Hum. Mol. Genet. (2005)
- The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Nagiec, M.M., Baltisberger, J.A., Wells, G.B., Lester, R.L., Dickson, R.C. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. van Slegtenhorst, M., Nellist, M., Nagelkerken, B., Cheadle, J., Snell, R., van den Ouweland, A., Reuser, A., Sampson, J., Halley, D., van der Sluijs, P. Hum. Mol. Genet. (1998)
- Identification and characterization of the interaction between tuberin and 14-3-3zeta. Nellist, M., Goedbloed, M.A., de Winter, C., Verhaaf, B., Jankie, A., Reuser, A.J., van den Ouweland, A.M., van der Sluijs, P., Halley, D.J. J. Biol. Chem. (2002)
- A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis. Hanada, K., Hara, T., Nishijima, M., Kuge, O., Dickson, R.C., Nagiec, M.M. J. Biol. Chem. (1997)
- Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity. Pinto, W.J., Wells, G.W., Lester, R.L. J. Bacteriol. (1992)
- Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Tamura, K., Mitsuhashi, N., Hara-Nishimura, I., Imai, H. Plant Cell Physiol. (2001)
- Integrative transformation system for the metabolic engineering of the sphingoid base-producing yeast Pichia ciferrii. Bae, J.H., Sohn, J.H., Park, C.S., Rhee, J.S., Choi, E.S. Appl. Environ. Microbiol. (2003)
- The topology of the Lcb1p subunit of yeast serine palmitoyltransferase. Han, G., Gable, K., Yan, L., Natarajan, M., Krishnamurthy, J., Gupta, S.D., Borovitskaya, A., Harmon, J.M., Dunn, T.M. J. Biol. Chem. (2004)
- Suppressors of the Ca(2+)-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. Cloning and characterization of SCS1, a gene required for serine palmitoyltransferase activity. Zhao, C., Beeler, T., Dunn, T. J. Biol. Chem. (1994)
- Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Urano, J., Comiso, M.J., Guo, L., Aspuria, P.J., Deniskin, R., Tabancay, A.P., Kato-Stankiewicz, J., Tamanoi, F. Mol. Microbiol. (2005)
- Sphingolipid synthesis: identification and characterization of mammalian cDNAs encoding the Lcb2 subunit of serine palmitoyltransferase. Nagiec, M.M., Lester, R.L., Dickson, R.C. Gene (1996)
- Tsc3p is an 80-amino acid protein associated with serine palmitoyltransferase and required for optimal enzyme activity. Gable, K., Slife, H., Bacikova, D., Monaghan, E., Dunn, T.M. J. Biol. Chem. (2000)
- Differential regulation of ceramide synthase components LAC1 and LAG1 in Saccharomyces cerevisiae. Kolaczkowski, M., Kolaczkowska, A., Gaigg, B., Schneiter, R., Moye-Rowley, W.S. Eukaryotic Cell (2004)
- Expression of a Novel Marine Viral Single-chain Serine Palmitoyltransferase and Construction of Yeast and Mammalian Single-chain Chimera. Han, G., Gable, K., Yan, L., Allen, M.J., Wilson, W.H., Moitra, P., Harmon, J.M., Dunn, T.M. J. Biol. Chem. (2006)
- Characterization of two novel yeast strains used in mediated biosensors for wastewater. Trosok, S.P., Luong, J.H., Juck, D.F., Driscoll, B.T. Can. J. Microbiol. (2002)