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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PTC4  -  type 2C protein phosphatase PTC4

Saccharomyces cerevisiae S288c

Synonyms: GCT1, PP2C-4, Protein phosphatase 2C homolog 4, YBR0921, YBR125C
 
 
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High impact information on PTC4

  • Overexpression of PTC4 led to a decrease in the high osmolarity-induced Hog1 phosphorylation, and HOG1 deletion remarkably suppressed the synthetic lethality, indicating an antagonistic role of the high osmolarity glycerol (HOG) pathway and the Ca(2+) signaling pathway in growth regulation [1].
  • A PTC4 cDNA that encodes a protein phosphatase belonging to the PP2C family was obtained as a high dosage suppressor of the lethality of Delta cnb1 Delta mpk1 strain [1].

References

  1. Evidence for antagonistic regulation of cell growth by the calcineurin and high osmolarity glycerol pathways in Saccharomyces cerevisiae. Shitamukai, A., Hirata, D., Sonobe, S., Miyakawa, T. J. Biol. Chem. (2004) [Pubmed]
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