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Gene Review

PTC4  -  type 2C protein phosphatase PTC4

Saccharomyces cerevisiae S288c

Synonyms: GCT1, PP2C-4, Protein phosphatase 2C homolog 4, YBR0921, YBR125C
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High impact information on PTC4

  • Overexpression of PTC4 led to a decrease in the high osmolarity-induced Hog1 phosphorylation, and HOG1 deletion remarkably suppressed the synthetic lethality, indicating an antagonistic role of the high osmolarity glycerol (HOG) pathway and the Ca(2+) signaling pathway in growth regulation [1].
  • A PTC4 cDNA that encodes a protein phosphatase belonging to the PP2C family was obtained as a high dosage suppressor of the lethality of Delta cnb1 Delta mpk1 strain [1].


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