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Gene Review

DER1  -  Der1p

Saccharomyces cerevisiae S288c

Synonyms: Degradation in the endoplasmic reticulum protein 1, YBR1413, YBR201W
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High impact information on DER1

  • Substrates with misfolded intramembrane domains define a pathway (ERAD-M) that differs from ERAD-L by being independent of Usa1p and Der1p [1].
  • We have identified a new pathway of ER-associated degradation in Saccharomyces cerevisiae that functions separately from the HRD/DER pathway comprised of Hrd1p, Hrd3p, Der1p, and Ubc7p [2].
  • Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast [3].
  • The depletion of Der1 from cells causes neither detectable growth phenotypes nor a general accumulation of unfolded proteins in the ER [3].
  • Further, we observed that mutations in proteins directly involved in degradation of malfolded proteins (Der1p, Der3/Hrd1p, and Hrd3p) lead to morphological changes of the endoplasmic reticulum and the Golgi, escape of CPY* into the secretory pathway and a slower maturation rate of wild-type CPY [4].

Biological context of DER1


Anatomical context of DER1


Other interactions of DER1


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