Gene Review:
HRD3 - ubiquitin ligase complex subunit HRD3
Saccharomyces cerevisiae S288c
Synonyms:
ERAD-associated E3 ubiquitin-protein ligase component HRD3, HMG-CoA reductase degradation protein 3, YLR207W
- A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Denic, V., Quan, E.M., Weissman, J.S. Cell (2006)
- The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. Gauss, R., Sommer, T., Jarosch, E. EMBO J. (2006)
- An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. Haynes, C.M., Caldwell, S., Cooper, A.A. J. Cell Biol. (2002)
- Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. Gardner, R.G., Swarbrick, G.M., Bays, N.W., Cronin, S.R., Wilhovsky, S., Seelig, L., Kim, C., Hampton, R.Y. J. Cell Biol. (2000)
- HRD gene dependence of endoplasmic reticulum-associated degradation. Wilhovsky, S., Gardner, R., Hampton, R. Mol. Biol. Cell (2000)
- Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. Plemper, R.K., Bordallo, J., Deak, P.M., Taxis, C., Hitt, R., Wolf, D.H. J. Cell. Sci. (1999)
- Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase. Saito, Y., Yamanushi, T., Oka, T., Nakano, A. J. Biochem. (1999)
- ER signaling in unfolded protein response. Kaneko, M., Nomura, Y. Life Sci. (2003)
- Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Hampton, R.Y., Gardner, R.G., Rine, J. Mol. Biol. Cell (1996)