Gene Review:
HRD1 - E3 ubiquitin-protein ligase HRD1
Saccharomyces cerevisiae S288c
Synonyms:
DER3, ERAD-associated E3 ubiquitin-protein ligase HRD1, HMG-CoA reductase degradation protein 1, YOL013C
- Induction of murine HRD1 in experimental cerebral ischemia. Qi, X., Okuma, Y., Hosoi, T., Kaneko, M., Nomura, Y. Brain Res. Mol. Brain Res. (2004)
- A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Denic, V., Quan, E.M., Weissman, J.S. Cell (2006)
- Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Bays, N.W., Gardner, R.G., Seelig, L.P., Joazeiro, C.A., Hampton, R.Y. Nat. Cell Biol. (2001)
- The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment. Gauss, R., Sommer, T., Jarosch, E. EMBO J. (2006)
- An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. Haynes, C.M., Caldwell, S., Cooper, A.A. J. Cell Biol. (2002)
- ER signaling in unfolded protein response. Kaneko, M., Nomura, Y. Life Sci. (2003)
- Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation. Plemper, R.K., Bordallo, J., Deak, P.M., Taxis, C., Hitt, R., Wolf, D.H. J. Cell. Sci. (1999)
- Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. Kaneko, M., Ishiguro, M., Niinuma, Y., Uesugi, M., Nomura, Y. FEBS Lett. (2002)
- Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. Kikkert, M., Doolman, R., Dai, M., Avner, R., Hassink, G., van Voorden, S., Thanedar, S., Roitelman, J., Chau, V., Wiertz, E. J. Biol. Chem. (2004)
- Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. Gardner, R.G., Swarbrick, G.M., Bays, N.W., Cronin, S.R., Wilhovsky, S., Seelig, L., Kim, C., Hampton, R.Y. J. Cell Biol. (2000)
- Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Deng, M., Hochstrasser, M. Nature (2006)
- A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae. Bordallo, J., Wolf, D.H. FEBS Lett. (1999)
- Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Hampton, R.Y., Gardner, R.G., Rine, J. Mol. Biol. Cell (1996)
- Ubiquitin-dependent 26S proteasomal pathway: a role in the degradation of native human liver CYP3A4 expressed in Saccharomyces cerevisiae? Murray, B.P., Correia, M.A. Arch. Biochem. Biophys. (2001)
- Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Bordallo, J., Plemper, R.K., Finger, A., Wolf, D.H. Mol. Biol. Cell (1998)