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Gene Review

ITC1  -  Itc1p

Saccharomyces cerevisiae S288c

Synonyms: G2842, Imitation switch two complex protein 1, YGL133W
 
 
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High impact information on ITC1

  • The imitation switch (ISWI) complex from yeast containing the Isw2 and Itc1 proteins was shown to preferentially slide mononucleosomes with as little as 23 bp of linker DNA from the end to the center of DNA [1].
  • Although the truncated form of ITC1 clearly suppressed the Ino(-) phenotype of the Delta hac1 strain, the full-length ITC1 had a moderate effect [2].
  • The activation of the pheromone signalling pathway in itc1 mutants of both mating types was examined and found to be constitutively active in MATalpha itc1 but not in MATa itc1 cells [3].
 

Biological context of ITC1

  • We identified the second subunit of Isw2 complex, encoded by open reading frame YGL 133w (herein named ITC1), and found that both subunits of the complex, Isw2p and Itc1p, are essential for efficient interaction with DNA and nucleosomal arrays [4].
  • The gene products of ITC1 and ISW2 are known to constitute a chromatin-remodeling complex (T. Tsukiyama, J. Palmer, C. C. Landel, J. Shiloach, and C. Wu, Genes Dev. 13:686--697, 1999) [2].
 

Other interactions of ITC1

  • Our results suggest that Isw2 and Itc1 proteins do not have the same impact on the described phenomenon [5].

References

 
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