Gene Review:
HAC1 - Hac1p
Saccharomyces cerevisiae S288c
Synonyms:
ERN4, IRE15, IRE2, Transcriptional activator HAC1, YFL031W
- Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. Cronin, S.R., Rao, R., Hampton, R.Y. J. Cell Biol. (2002)
- Portability and fidelity of RNA-repair systems. Schwer, B., Sawaya, R., Ho, C.K., Shuman, S. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein response. Rüegsegger, U., Leber, J.H., Walter, P. Cell (2001)
- XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Yoshida, H., Matsui, T., Yamamoto, A., Okada, T., Mori, K. Cell (2001)
- The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Sidrauski, C., Walter, P. Cell (1997)
- The unfolded protein response is required for haploid tolerance in yeast. Lee, K., Neigeborn, L., Kaufman, R.J. J. Biol. Chem. (2003)
- IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast. Schröder, M., Clark, R., Kaufman, R.J. Mol. Microbiol. (2003)
- Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expression. Nikawa, J., Akiyoshi, M., Hirata, S., Fukuda, T. Nucleic Acids Res. (1996)
- IRE1 and efferent signaling from the endoplasmic reticulum. Urano, F., Bertolotti, A., Ron, D. J. Cell. Sci. (2000)
- The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. Schröder, M., Clark, R., Liu, C.Y., Kaufman, R.J. EMBO J. (2004)
- Differences in HAC1 mRNA processing and translation between yeast and mammalian cells indicate divergence of the eukaryotic ER stress response. Bowring, C.E., Llewellyn, D.H. Biochem. Biophys. Res. Commun. (2001)
- The cellular response to protein misfolding in the endoplasmic reticulum. Welihinda, A.A., Tirasophon, W., Kaufman, R.J. Gene Expr. (1999)
- tRNA ligase is required for regulated mRNA splicing in the unfolded protein response. Sidrauski, C., Cox, J.S., Walter, P. Cell (1996)
- Global and specific translational regulation in the genomic response of Saccharomyces cerevisiae to a rapid transfer from a fermentable to a nonfermentable carbon source. Kuhn, K.M., DeRisi, J.L., Brown, P.O., Sarnow, P. Mol. Cell. Biol. (2001)
- The Saccharomyces cerevisiae Isw2p-Itc1p complex represses INO1 expression and maintains cell morphology. Sugiyama, M., Nikawa, J. J. Bacteriol. (2001)
- Homocysteine- and cysteine-mediated growth defect is not associated with induction of oxidative stress response genes in yeast. Kumar, A., John, L., Alam, M.M., Gupta, A., Sharma, G., Pillai, B., Sengupta, S. Biochem. J. (2006)
- A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Tirasophon, W., Welihinda, A.A., Kaufman, R.J. Genes Dev. (1998)
- Essential role of calcineurin in response to endoplasmic reticulum stress. Bonilla, M., Nastase, K.K., Cunningham, K.W. EMBO J. (2002)
- Hac1: a novel yeast bZIP protein binding to the CRE motif is a multicopy suppressor for cdc10 mutant of Schizosaccharomyces pombe. Nojima, H., Leem, S.H., Araki, H., Sakai, A., Nakashima, N., Kanaoka, Y., Ono, Y. Nucleic Acids Res. (1994)
- Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Welihinda, A.A., Tirasophon, W., Green, S.R., Kaufman, R.J. Mol. Cell. Biol. (1998)
- Stress-induced transcription of the endoplasmic reticulum oxidoreductin gene ERO1 in the yeast Saccharomyces cerevisiae. Takemori, Y., Sakaguchi, A., Matsuda, S., Mizukami, Y., Sakurai, H. Mol. Genet. Genomics (2006)
- ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode, I., Maiwald, D., Hollenberg, C.P., Suckow, M. J. Mol. Biol. (2002)
- Yeast unfolded protein response pathway regulates expression of genes for anti-oxidative stress and for cell surface proteins. Kimata, Y., Ishiwata-Kimata, Y., Yamada, S., Kohno, K. Genes Cells (2006)
- The REC41 gene of Saccharomyces cerevisiae: isolation and genetic analysis. Chepurnaya, O.V., Kozhina, T.N., Peshekhonov, V.T., Korolev, V.G. Mutat. Res. (2001)
- The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo. Welihinda, A.A., Tirasophon, W., Kaufman, R.J. J. Biol. Chem. (2000)
- Effects of inactivation and constitutive expression of the unfolded- protein response pathway on protein production in the yeast Saccharomyces cerevisiae. Valkonen, M., Penttilä, M., Saloheimo, M. Appl. Environ. Microbiol. (2003)