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Gene Review

RPS0A  -  ribosomal 40S subunit protein S0A

Saccharomyces cerevisiae S288c

Synonyms: 40S ribosomal protein S0-A, NAB1, NAB1A, Nucleic acid-binding protein NAB1A, YGR214W, ...
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High impact information on RPS0A

  • The TIF32-CTD interacted in vitro with helices 16-18 of domain I in 18S rRNA, and the TIF32-NTD and NIP1 interacted with 40S protein RPS0A [1].
  • Yeast homologues of p40/37-LRP are encoded by a duplicated pair of genes, RPS0A and RPS0B [2].
  • Moreover, the growth arrest of TOM1 mutants at elevated temperatures is partially suppressed by overexpression of RPS0A/B [3].
  • Gene sequencing revealed that RTA1 is adjacent to the NAB1 gene which is orientated in an opposite direction and localized on chromosome VII [4].

Anatomical context of RPS0A

  • Compared to wild type, polysome profiles in strains lacking either YST1 or YST2 show a pronounced shift from larger to smaller polysomes [5].

Other interactions of RPS0A

  • Strains with mutant alleles of TOM1 are defective in multiple steps in rRNA processing, and interactions between RPS0A/B and TOM1 stem, in part, from their roles in the maturation of ribosomal subunits [3].


  1. The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo. Valásek, L., Mathew, A.A., Shin, B.S., Nielsen, K.H., Szamecz, B., Hinnebusch, A.G. Genes Dev. (2003) [Pubmed]
  2. Yeast proteins related to the p40/laminin receptor precursor are required for 20S ribosomal RNA processing and the maturation of 40S ribosomal subunits. Ford, C.L., Randal-Whitis, L., Ellis, S.R. Cancer Res. (1999) [Pubmed]
  3. Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. Tabb, A.L., Utsugi, T., Wooten-Kee, C.R., Sasaki, T., Edling, S.A., Gump, W., Kikuchi, Y., Ellis, S.R. Genetics (2001) [Pubmed]
  4. Characterization of the Saccharomyces cerevisiae RTA1 gene involved in 7-aminocholesterol resistance. Soustre, I., Letourneux, Y., Karst, F. Curr. Genet. (1996) [Pubmed]
  5. Yeast proteins related to the p40/laminin receptor precursor are essential components of the 40 S ribosomal subunit. Demianova, M., Formosa, T.G., Ellis, S.R. J. Biol. Chem. (1996) [Pubmed]
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