Disease relevance of LAMR1

• Interleukin-12 p40 mRNA expression in bovine leukemia virus-infected animals: increase in alymphocytosis but decrease in persistent lymphocytosis [1].
• The p40* adhesin pseudogene of Mycoplasma bovis [2].
• A recombinant baculovirus expressing p35His was generated and used for superinfection with a recombinant baculovirus expressing p40 subunit [3].
• Buffalo IL-12 p40 recombinant protein expressed in Escherichia coli cross-reacted with cattle anti-IL-12 p40 monoclonal antibody [4].

High impact information on LAMR1

• ARPC1 p40 is a seven-blade beta propeller with an insertion that may associate with the side of an actin filament [5].
• Further, while both peaks are isoprenylated, the isoprenyl groups consist of mixtures of C5, C10, C15, and C20 isoprenyl moieties [6].
• In order to prepare a completely light-stable rhodopsin, we have synthesized an analog, II, of 11-cis retinal in which isomerization at the C11-C12 cis-double bond is blocked by formation of a cyclohexene ring from the C10 to C13-methyl [7].
• The methyl-acceptor activities of a variety of n-alkyl S-derivatives of LARYKC (C8, C10, C13, C15) were also tested; all of these compounds were poorer substrates than the S-geranyl derivative [8].
• BSA binds the n-alkanols specifically and, at 1 mM total concentration, is stabilized with increasing potency up to decanol (C10), where a loss in stabilizing potency occurs [9].

Biological context of LAMR1

• The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation [10].
• On the basis of the spectral properties of fluorinated analogues, a polar group in the chromophore binding site of iodopsin as well as rhodopsin was estimated to be located near the hydrogen atom at the C10 position of the retinylidene chromophore [11].
• During the first week of parturition, the proportions of short-chain fatty acids (C4-C10) typically increased as well as those of stearic and oleic acids, whereas the relative amounts of C12-C16 acids decreased, especially those of myristic and palmitic acids [12].
• P-glycoprotein interaction was examined using a rhodamine assay and it was found that simple hydrolysis or epimerization of the C10 acetate of paclitaxel and Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain [13].
• Nucleotide sequence analysis of the p40* gene in M. bovis revealed the presence of a large deletion involving a frameshift that causes premature truncation of the translated protein, indicating that p40* exists as a pseudogene in M. bovis [2].

Anatomical context of LAMR1

• In endothelial cells, endogenous TIMAP and LAMR1 co-immunoprecipitated and co-localized at the plasma membrane [10].
• Biochemical properties of a cytosolic protein-tyrosine kinase (CPTK-40) partially purified from porcine spleen were characterized and compared with p40 kinase, a cytosolic protein-tyrosine kinase from bovine thymus [14].
• The goat mammary microsomal fraction was not able to induce C10 synthesis by rat and rabbit mammary-gland fatty acid synthetase, but only by the goat and cow enzyme [15].
• This acidic sequence has considerable similarity to the site recognized by p40 in erythrocyte band 3 protein [16].
• Glycogen synthase from rabbit skeletal muscle was found to be phosphorylated by a protein-tyrosine kinase, p40, purified from bovine thymus [16].

Associations of LAMR1 with chemical compounds

• The nitroxide with a C10 chain was less effective in this system [17].
• Three distinct indolinic nitroxides were synthesized and compared with vitamin E and Trolox (a hydrophilic analogue of vitamin E), where the only difference between the nitroxides was the length of the hydrocarbon chain in the 2-position of indole, namely 2 (C2), 10 (C10), and 18 (C18) carbons [17].
• This fact suggests that the fluorine substituent at the C10 position (i.e., 10-fluoro) of the retinylidene chromophore may interact with the protein moiety during the process of isomerization of the chromophore or in the state of the batho intermediate [18].
• We find that casein kinase-1 can phosphorylate the p40 tyrosyl kinase on serine and threonine residues, in part on a unique tryptic peptide [19].
• The inhibitory activity showed a very strong configuration dependence, a major contribution from the ester groups at C3 and C10, and an apparently minor contribution from the lactone ring substituents [20].

Physical interactions of LAMR1

• We found that TIMAP interacts with the 37/67 kDa laminin receptor (LAMR1) in yeast two-hybrid assays [10].

Other interactions of LAMR1

• In MDCK cells, PP-1 associated with LAMR1 in the presence, but not in the absence, of TIMAP [10].

Analytical, diagnostic and therapeutic context of LAMR1

• Transcription of recombinant BLVenv, bovine IL4, p35 and p40 was demonstrated by RT-PCR [21].

References